Chicago White Sox vs New York Yankees MLB Betting Prediction
PublishedSeptember 25, 2025,            Posted By: Maria Uebelhor
Last updated:September 25, 2025 ,

MLB Chicago White Sox vs New York Yankees Prediction 9/25

The Chicago White Sox will take on the New York Yankees on Thursday, September 25, 2025, at 7:05 PM. The game will be held at Yankee Stadium in New York, NY. The weather forecast predicts moderate rain with a light breeze. The White Sox have a record of 58-100, while the Yankees hold a record of 90-68.

White Sox vs. Yankees Betting Prediction

  • Money Line Prediction: New York Yankees at -304. The Yankees have a strong home record and are on a winning streak. The White Sox have struggled on the road and have lost their last four games.
  • Over/Under Prediction: Under 8.5 (-106). The Yankees have a solid pitching lineup, and the White Sox have not been scoring many runs lately. The weather forecast also suggests moderate rain, which might affect scoring.

Team Trends

  • New York Yankees have a strong home record of 46-31 this season.
  • Chicago White Sox have struggled on the road with a record of 25-52.
  • New York Yankees are on a 4-game winning streak and have won 7 of their last 10 games.
  • Chicago White Sox are on a 4-game losing streak and have won only 1 of their last 10 games.
  • The weather forecast for the game is moderate rain with a light breeze crosswind.

White Sox vs Yankees Preview

The Chicago White Sox are visiting Yankee Stadium to play against the New York Yankees. The White Sox have had a tough season, sitting at the bottom of their division with a record of 58-100. They have lost their last four games and have struggled to find wins recently, going 1-9 in their last ten games.

On the mound for the White Sox is Davis Martin, who has an ERA of 4.03 and a WHIP of 1.27. He has a record of 7-10 this season. The Yankees, on the other hand, are leading their division with a record of 90-68. They have won their last four games and have a strong recent record of 7-3. Carlos Rodón will start for the Yankees, holding an ERA of 3.04 and a WHIP of 1.06. Rodón’s record is 17-9 this season, making him a key player for the Yankees. The game is set for a 7:05 PM start, with moderate rain expected.

Yankees Ready to Swing for the Fences

The New York Yankees have some strong hitters this season. Jazz Chisholm Jr. leads the team in home runs with 31. He also has the highest team rank in runs with 75. Anthony Volpe has played in 149 games. He has hit 19 home runs and scored 65 runs. His batting average is .213. Ben Rice has hit 24 home runs this season. He has a batting average of .256. Rice ranks second on the team in home runs and runs scored.

White Sox Seek Strong Finish

The Chicago White Sox have some key players in their lineup. Lenyn Sosa has the highest batting average among the top hitters at .259. He also leads the team in home runs with 21. His 72 RBIs are the most on the team. Miguel Vargas is another important player for the White Sox. He has played 135 games and has a batting average of .231. Vargas leads the team in runs with 74 and is third in home runs with 15. On the pitching side, Davis Martin will start for the White Sox. He has an ERA of 4.03 and a WHIP of 1.27. Martin’s record for the season is 7 wins and 10 losses.

Final Betting Pick

The Yankees are a strong pick for the money line at -304. They have a solid home record of 46-31 and are currently on a winning streak. Their recent performance against the White Sox, winning 8-1 and 3-2, shows their ability to dominate at home.

For the over/under prediction, the under 8.5 at -106 looks favorable. The Yankees’ pitching, led by Carlos Rodón with a 3.04 ERA, is strong. The White Sox have struggled to score, as seen in their recent games, where they failed to score more than three runs. The weather forecast of moderate rain could also limit scoring opportunities.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.