Cincinnati Reds vs Arizona Diamondbacks MLB Betting Prediction
PublishedAugust 22, 2025,            Posted By: Maria Uebelhor
Last updated:August 22, 2025 ,

MLB Cincinnati Reds vs Arizona Diamondbacks Prediction 8/22

The Cincinnati Reds will visit the Arizona Diamondbacks at Chase Field on Friday, August 22, 2025. The game is set to start at 9:40 PM. The Reds have a record of 67-61, while the Diamondbacks stand at 62-66.

Reds vs. Diamondbacks Betting Prediction

  • Money Line Prediction: Cincinnati Reds +115. The Reds have a slightly better recent form with a 6-4 record in their last 10 games. They also have a strong road record, which may give them an edge against the Diamondbacks.
  • Over/Under Prediction: Under 9.0 (-109). Both starting pitchers, Zack Littell and Ryne Nelson, have ERAs under 4.00, indicating a potential low-scoring game.

Team Trends

  • The Cincinnati Reds have a road record of 31-32 this season.
  • The Arizona Diamondbacks hold a home record of 32-31 this season.
  • Cincinnati Reds’ manager is Terry Francona.
  • Arizona Diamondbacks’ manager is Torey Lovullo.
  • Chase Field in Phoenix, AZ, features a retractable roof.

Reds vs Diamondbacks Preview

The Cincinnati Reds will take on the Arizona Diamondbacks at Chase Field on Friday night. The Reds hold a record of 67-61 and are ranked third in their division. They have won six of their last ten games but are coming off a loss. Zack Littell will start for the Reds, bringing an ERA of 3.52 and a WHIP of 1.11 into the game.

The Arizona Diamondbacks have a record of 62-66 and are also third in their division. They have a two-game winning streak and have split their last ten games. Ryne Nelson will be on the mound for the Diamondbacks, with an ERA of 3.58 and a WHIP of 1.07. The game will be played under a retractable roof, so the very hot weather outside may not affect the players.

Arizona Diamondbacks: Home Team Overview

The Arizona Diamondbacks have a solid lineup this season. Geraldo Perdomo leads the team with a .287 batting average and has played in 127 games. Ketel Marte also shines with a .293 average and 23 home runs. Ryne Nelson is the starting pitcher for the Diamondbacks in this game. He has an ERA of 3.58 and a WHIP of 1.07. Nelson’s record stands at 6 wins and 3 losses. As a team, the Diamondbacks rank 7th in batting average with a .251. They are 5th in on-base percentage at .324 and 3rd in slugging percentage at .439. The team has hit 178 home runs, ranking 5th in the league.

Cincinnati Reds: Away Team Insights

The Cincinnati Reds have a strong lineup this season. Elly De La Cruz leads the team with a .273 batting average. He has hit 19 home runs and scored 89 runs, ranking first on the team in these categories. Spencer Steer is another key player for the Reds. He has a .238 batting average with 15 home runs. Steer has played in 118 games, contributing to the team’s performance. Zack Littell is the starting pitcher for this game. He has an ERA of 3.52 and a WHIP of 1.11. Littell has a record of 9 wins and 8 losses this season.

Final Betting Pick

The Cincinnati Reds have shown strong form recently, with a 6-4 record in their last 10 games. Their road record of 31-32 is slightly below average, but they have managed to secure important wins away from home. This could give them an edge against the Arizona Diamondbacks, who have a home record of 32-31.

The prediction for the game to go under 9.0 runs seems reasonable given the starting pitchers. Zack Littell for the Reds has an ERA of 3.52, while Ryne Nelson for the Diamondbacks has an ERA of 3.58. Both pitchers have been effective at limiting runs, which could lead to a low-scoring game.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.