The Cleveland Guardians will visit the Minnesota Twins on Sunday, September 21, 2025, at 2:10 PM. The game will take place at Target Field in Minneapolis, MN. Fans can expect mild weather with a light breeze and overcast clouds. The Guardians are on a ten-game winning streak, while the Twins have lost their last five games. Catch the action on MNNT.

Guardians vs. Twins Betting Prediction

• Money Line Prediction: Cleveland Guardians at -128. The Guardians are on a 10-game win streak and have been strong on the road with a 43-37 record. Meanwhile, the Twins have lost their last 5 games and have struggled at home with a 37-43 record.
• Over/Under Prediction: Under 8.5 (-115). The Guardians have allowed only 2 runs in their last 3 games against the Twins. With both teams’ recent performances, a low-scoring game is likely.

Team Trends

• The Cleveland Guardians have a strong road record of 43-37 this season.
• The Minnesota Twins have struggled at home with a record of 37-43.
• The Guardians are currently on a 10-game winning streak.
• The Twins are on a 5-game losing streak.
• In their last game, the Guardians defeated the Twins 8-0 with Logan Allen pitching 8 scoreless innings.

Guardians vs Twins Preview

The Cleveland Guardians are rolling with a ten-game winning streak. They hold a strong record of 84-71 and sit second in their division. Joey Cantillo will take the mound for the Guardians. He has an ERA of 3.27 and a WHIP of 1.30. Cantillo’s performance will be key as the Guardians aim to extend their winning run.

On the other side, the Minnesota Twins are in a slump, losing their last five games. Their current record is 66-89, placing them fourth in the division. Simeon Woods Richardson will start for the Twins. He has an ERA of 4.31 and a WHIP of 1.35. The Twins will look to break their losing streak with a strong showing at home.

Twins’ Key Players and Stats

Brooks Lee plays third base for the Twins. He has played 132 games this season. Lee has a batting average of .239 and has hit 15 home runs, ranking second on the team. Ryan Jeffers is the Twins’ catcher. He has a batting average of .262 in 114 games. Jeffers has hit 9 home runs and scored 47 runs, placing him second on the team for runs. Kody Clemens plays second base for the Twins. He has hit 19 home runs, the most on the team. Clemens has played in 112 games and has a slugging percentage of .442.

Cleveland Guardians: Players to Watch

José Ramírez plays third base for the Guardians. He has a batting average of .282 in 151 games. Ramírez leads the team with 30 home runs and 100 runs scored. Kyle Manzardo is the first baseman for the Guardians. He has played 135 games with a batting average of .235. Manzardo has hit 26 home runs and has 68 RBIs, placing him second on the team in both categories. Gabriel Arias plays shortstop for the Guardians. He has a batting average of .225 in 122 games. Arias has hit 11 home runs and scored 43 runs this season.

Final Betting Pick

The Cleveland Guardians are looking strong for this game. They have a 10-game win streak and are performing well on the road with a 43-37 record. Their recent games against the Twins show they have allowed only 2 runs in the last 3 games. This makes the Guardians a solid pick at -128 on the money line.

The Twins are struggling, having lost their last 5 games and have a home record of 37-43. Their recent performance against the Guardians has been poor, with no runs scored in the last two games. With the Guardians’ strong pitching and the Twins’ struggles, the under 8.5 at -115 is a good choice for a low-scoring game.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.