Detroit Tigers vs Cleveland Guardians MLB Betting Prediction
PublishedOctober 1, 2025,            Posted By: Maria Uebelhor
Last updated:October 1, 2025 ,

MLB Detroit Tigers vs Cleveland Guardians Prediction 10/1

The Detroit Tigers will play against the Cleveland Guardians on Wednesday, October 1, 2025. The game will take place at Progressive Field in Cleveland, OH. The weather is expected to be clear with a light breeze, making it a nice day for baseball. The Tigers are currently leading the division with a 1-0 record, while the Guardians are looking to bounce back from a loss. The game starts at 1:08 PM.

Tigers vs. Guardians Betting Prediction

  • Money Line Prediction: Detroit Tigers +109. The Tigers have a slight edge with Casey Mize starting, who had a better win-loss record this season. They also recently defeated the Guardians in their last meeting.
  • Over/Under Prediction: Under 6.5 (-105). Both teams have solid pitching, and previous games between these teams have often been low-scoring.

Team Trends

  • The Detroit Tigers have a road record of 41-40 this season.
  • The Cleveland Guardians have a home record of 45-36 this season.
  • In their last game against the Guardians, the Tigers won 4-2.
  • The Guardians recently won a high-scoring game against the Texas Rangers, 9-8.
  • The game will be played at Progressive Field with clear skies and a light breeze.

Tigers vs Guardians Preview

The Detroit Tigers and Cleveland Guardians are set to meet at Progressive Field on Wednesday. The Tigers are off to a strong start with a 1-0 record and hold the top spot in the division. Meanwhile, the Guardians are eager to recover from their opening loss. Fans can expect a clear sky and a light breeze, making it a great day for baseball.

Casey Mize will take the mound for the Tigers. He had a solid season last year with a 3.87 ERA and a 14-6 record. The Guardians will counter with Tanner Bibee, who posted a 4.24 ERA and a 12-11 record. Both pitchers will aim to give their teams an edge in this early season game.

Cleveland Guardians: Key Players and Stats

José Ramírez is the top hitter for the Cleveland Guardians. He played 158 games with a batting average of .283. Ramírez also hit 30 home runs, ranking 15th in the league. Kyle Manzardo adds power to the lineup with 27 home runs. He played 142 games with a batting average of .234. Manzardo scored 47 runs, which is third on the team. Tanner Bibee will start for the Guardians. His ERA is 4.24, and he has a record of 12-11. Bibee will look to improve his stats against the Tigers.

Detroit Tigers: Players to Watch and Pitching Edge

Spencer Torkelson is a key player for the Detroit Tigers. He played 155 games and has a batting average of .240. Torkelson hit 31 home runs, which ranks 14th in the league. Gleyber Torres adds depth to the Tigers’ lineup. He played 145 games with a batting average of .256. Torres hit 16 home runs and scored 79 runs. Casey Mize will start for the Tigers against the Guardians. Mize has an ERA of 3.87 and a record of 14-6. His WHIP is 1.27, which shows good control on the mound.

Final Betting Pick

The Detroit Tigers at +109 on the money line is a solid choice. Casey Mize is starting, and his 14-6 win-loss record gives the Tigers an advantage. The Tigers have a decent road record of 41-40, which boosts their chances against the Guardians.

For the over/under prediction, choosing under 6.5 is wise. Both teams have strong pitching, with Mize’s ERA at 3.87 and Tanner Bibee’s at 4.24. Recent games between these teams have been low-scoring, supporting the under pick.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.