The San Francisco Giants will play against the Arizona Diamondbacks on Wednesday, September 17, 2025, at Chase Field in Phoenix, AZ. The Giants hold a record of 75-76 and are ranked fourth in their division. The Diamondbacks are third in the division with a record of 77-75. The game will be broadcast on MLBN, and the weather is expected to be very hot with overcast clouds.

Giants vs. Diamondbacks Betting Prediction

• Money Line Prediction: Arizona Diamondbacks -112. The Diamondbacks have a better home record and are on a winning streak. The Giants have struggled recently, losing their last four games.
• Over/Under Prediction: Over 9.0 (-106). Both teams have shown strong hitting in recent games, with the Diamondbacks scoring consistently high and the Giants capable of putting up runs.

Team Trends

• The Arizona Diamondbacks are on a 4-game winning streak and have a home record of 40-34.
• The San Francisco Giants have lost their last 4 games and have a road record of 37-39.
• The game will be played at Chase Field in Phoenix, AZ, which has a retractable roof.
• In their last game, the Diamondbacks won 6-5 against the Giants with 13 hits and 1 home run.
• The Giants’ manager is Bob Melvin, while the Diamondbacks are managed by Torey Lovullo.

Giants vs Diamondbacks Preview

The San Francisco Giants and Arizona Diamondbacks are set to meet at Chase Field. The Giants have struggled recently, losing their last four games. Their record is 75-76, placing them fourth in their division. On the mound for the Giants is Justin Verlander, who has an ERA of 3.94 and a record of 3-10. He will look to turn things around for his team.

The Diamondbacks, on the other hand, are on a four-game winning streak. They hold a record of 77-75 and are third in their division. Brandon Pfaadt will start for Arizona, carrying an ERA of 5.31 and a record of 13-8. The Diamondbacks aim to continue their winning ways in front of their home crowd.

Arizona Diamondbacks: Key Players and Stats

The Arizona Diamondbacks have a strong lineup this season. Geraldo Perdomo leads the team in runs and RBI with 94 and 97, respectively. Ketel Marte has hit the most home runs for the team with 25. Brandon Pfaadt will start as the pitcher for the Diamondbacks. He has a record of 13 wins and 8 losses. His ERA is 5.31, and his WHIP is 1.40. As a team, the Diamondbacks have a batting average of .252, ranking 7th in the league. They have hit 205 home runs this season. Their slugging percentage stands at .436, placing them 4th in the league.

San Francisco Giants: Power at the Plate

The Giants have some strong hitters in their lineup. Rafael Devers leads the team with 31 home runs and 102 RBI. Willy Adames follows with 28 home runs and 82 RBI. Matt Chapman adds depth with 21 home runs this season. The Giants’ team batting average is .237, which is 17th in the league. Their on-base percentage is .311, placing them 15th. The team’s slugging percentage of .388 ranks 20th. On the mound, Justin Verlander will start for the Giants. His ERA is 3.94, and his WHIP is 1.37. Verlander’s record this season is 3 wins and 10 losses.

Final Betting Pick

The Arizona Diamondbacks are a good pick for the money line at -112. They have a strong home record of 40-34 and are on a winning streak. The Giants, on the other hand, have struggled on the road with a 37-39 record and have lost their last four games.

The over 9.0 total is a solid choice due to both teams’ recent hitting performances. The Diamondbacks have been scoring well, as shown by their recent games with high run totals. The Giants have also shown they can put up runs, even in losses, making the over a reasonable bet.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.