The St. Louis Cardinals are set to play against the San Francisco Giants on Monday, September 22, 2025. The game will take place at Oracle Park in San Francisco, CA, starting at 9:45 PM. The weather forecast predicts a warm day with a light breeze and a few clouds. Tune in to NBCS to catch the action.

Cardinals vs. Giants Betting Prediction

• Money Line Prediction: St. Louis Cardinals +124. The Cardinals have a slight edge with Michael McGreevy on the mound. He has a better win-loss record than Justin Verlander, who has struggled with a 3-10 record.
• Over/Under Prediction: Under 8.0 (-113). Both teams have been inconsistent offensively, and with the wind blowing in at Oracle Park, runs could be limited.

Team Trends

• The St. Louis Cardinals have a road record of 32-43 this season.
• The San Francisco Giants hold a home record of 38-37 this season.
• In their last game, the St. Louis Cardinals won against the Milwaukee Brewers with a score of 5-1.
• The San Francisco Giants recently won 3-1 against the Los Angeles Dodgers.
• Both teams are on a one-game winning streak heading into this game.

Cardinals vs Giants Preview

The St. Louis Cardinals will meet the San Francisco Giants at Oracle Park. The Cardinals have a record of 76-80 and are ranked 4th in their division. Michael McGreevy will start for the Cardinals. He has an ERA of 4.08, a WHIP of 1.20, and a win-loss record of 7-3. The Cardinals are coming off a win and have gone 4-6 in their last 10 games.

The Giants hold a 77-79 record and also sit 4th in their division. Justin Verlander will take the mound for the Giants. He has an ERA of 3.75, a WHIP of 1.34, and a win-loss record of 3-10. The Giants have won their last game but have struggled recently, going 3-7 in their last 10 games. The game starts at 9:45 PM, and fans can watch it on NBCS.

San Francisco Giants: A Look at the Home Team

The San Francisco Giants have Rafael Devers leading their lineup. Devers has played 157 games with a batting average of .251. He has hit 32 home runs, ranking 11th in the league. Willy Adames adds depth to the Giants’ batting order. Adames has a batting average of .226 and has played in 154 games. He has contributed 28 home runs, placing him 15th in the league. On the mound, Justin Verlander is set to start for the Giants. Verlander has an ERA of 3.75 this season. His record stands at 3 wins and 10 losses.

St. Louis Cardinals: Key Players and Performance

The St. Louis Cardinals have several players who contribute to their lineup. Willson Contreras is a standout with a .257 batting average over 135 games. He has hit 20 home runs and scored 70 runs this season. Alec Burleson is another key player for the Cardinals. He has played 134 games with a .289 batting average. Burleson has added 18 home runs and 53 runs to the team’s total. On the mound, Michael McGreevy will start for the Cardinals. McGreevy has a 4.08 ERA and a record of 7 wins and 3 losses. His WHIP is 1.20, showing solid control on the mound.

Final Betting Pick

The Cardinals have a good chance with Michael McGreevy pitching. His 7-3 record is better than Justin Verlander’s 3-10. The Cardinals also have a recent win against the Brewers, showing they can perform on the road.

Betting on the under 8.0 is smart. Both teams have struggled to score consistently. The wind at Oracle Park might make it harder to hit home runs, keeping the score low. The Giants’ recent games have also been low-scoring, which supports this pick.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.