The Milwaukee Brewers take on the San Diego Padres on Tuesday, September 23, 2025, at 9:40 PM. The game will be held at PETCO Park in San Diego, CA. Fans can expect clear skies and a light breeze at this outdoor stadium.

Brewers vs. Padres Betting Prediction

• Money Line Prediction: San Diego Padres at -117. The Padres are on a 3-game winning streak and have a strong home record of 48-28. This makes them a solid choice against the Brewers, who have lost their last two games.
• Over/Under Prediction: Under 8.5 at -104. Both teams have strong pitching and have shown the ability to keep games low-scoring. The Brewers’ recent games have often stayed under this total.

Team Trends

• The Milwaukee Brewers have a road record of 44-35 this season.
• San Diego Padres have a home record of 48-28 this season.
• The Brewers are on a two-game losing streak, while the Padres have won their last three games.
• The Brewers recently lost to the Padres 5-4 on September 22, 2025.
• The Padres are 2 games behind in the NL West division.

Brewers vs Padres Preview

The Milwaukee Brewers, with a record of 95-62, are leading their division. They come into this game after two losses, aiming to regain their momentum. Their recent performance shows a 6-4 record over the last ten games. The Brewers have not yet announced their starting pitcher for this matchup.

The San Diego Padres hold a record of 86-71 and are second in their division. They are on a three-game winning streak, sharing the same 6-4 record over their last ten games. Randy Vásquez will take the mound for the Padres. He has a 3.94 ERA and a WHIP of 1.36 this season. The game will be played at PETCO Park, where clear skies and a light breeze are expected.

Padres Ready for Action

Manny Machado leads the San Diego Padres with strong numbers. He has a batting average of .274 and has played in 156 games. Machado is first on the team with 26 home runs and 93 RBIs. Luis Arraez is another key player for the Padres. He has a batting average of .286 in 150 games. Arraez has hit 7 home runs and scored 62 runs this season. Randy Vásquez will be the starting pitcher for the Padres. His ERA is 3.94, and he has a WHIP of 1.36. Vásquez has a record of 5 wins and 7 losses.

Brewers’ Key Players and Stats

Brice Turang is a standout player for the Milwaukee Brewers. He has played in 151 games with a batting average of .286. Turang leads the team with 18 home runs and 96 runs. William Contreras has made a strong impact as well. He has a batting average of .263 over 148 games. Contreras has hit 17 home runs and scored 89 runs this season. Caleb Durbin is another important player for the Brewers. He has played in 132 games with a batting average of .265. Durbin has 11 home runs and 60 runs.

Final Betting Pick

The San Diego Padres are a strong pick for the money line at -117. They are on a 3-game winning streak and have a solid home record of 48-28. Playing at PETCO Park gives them an edge, especially against the Brewers, who have lost their last two games on the road.

The under 8.5 total is also a good choice. Both teams have strong pitching, with the Padres’ Randy Vásquez having an ERA of 3.94. Recent games for the Brewers have often stayed under this total, showing their ability to keep scores low. This trend supports the under pick for this matchup.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.