Philadelphia Phillies vs Arizona Diamondbacks MLB Betting Prediction

MLB Philadelphia vs Arizona Diamondbacks Prediction 9/21

The Philadelphia Phillies will take on the Arizona Diamondbacks on Sunday, September 21, 2025, at Chase Field in Phoenix, AZ. The Phillies have a record of 92-63 and are ranked first in their division. The Diamondbacks hold a 78-77 record and are third in their division. The game will start at 4:10 PM and will be broadcast on NSPPH.

Phillies vs. Diamondbacks Betting Prediction

  • Money Line Prediction: Philadelphia Phillies -129. The Phillies have a strong road record and a better starting pitcher in Ranger Suárez, who has a low ERA of 2.84.
  • Over/Under Prediction: Over 9.0 (-109). Both teams have shown they can score runs, and with Eduardo Rodriguez’s higher ERA of 5.12, the game could see more than 9 runs.

Team Trends

  • Philadelphia Phillies have a 92-63 record, placing them 1st in the NL East.
  • Arizona Diamondbacks hold a 78-77 record, ranking 3rd in the NL West.
  • The Phillies have a road record of 41-39 this season.
  • The Diamondbacks have a home record of 41-36 this season.
  • Weather at Chase Field is forecasted to be very hot with clear skies.

Phillies vs Diamondbacks Preview

The Philadelphia Phillies travel to Chase Field to play against the Arizona Diamondbacks on Sunday, September 21, 2025. The Phillies lead their division with a strong 92-63 record. They recently lost a game but have been solid in their last ten games, going 7-3. Meanwhile, the Diamondbacks are third in their division with a 78-77 record. They are coming off a win and have a 6-4 record in their last ten games.

On the mound, the Phillies will have Ranger Suárez starting. He has a 2.84 ERA and a 12-6 win-loss record. The Diamondbacks will counter with Eduardo Rodriguez, who holds a 5.12 ERA and an 8-8 record. The game at Chase Field will start at 4:10 PM and will be shown on NSPPH. The weather is expected to be very hot, but the retractable roof might keep conditions stable inside the stadium.

Arizona Diamondbacks: Key Players and Stats

Geraldo Perdomo is a standout for the Diamondbacks this season. He has played 154 games with a batting average of .289. Perdomo leads the team in runs with 96 and RBIs with 97. Ketel Marte is another key player for Arizona. In 120 games, he holds a batting average of .279. Marte leads the team in home runs with 26 and ranks second in runs with 80. The Diamondbacks’ team batting average is .251, ranking 7th in the league. Their slugging percentage is .434, which is 3rd best. They have hit 206 home runs, placing them 7th in this category.

Philadelphia Phillies: Strong Performers and Stats

Kyle Schwarber is a key player for the Phillies. He has played 155 games with a batting average of .243. Schwarber leads the team in home runs with 53 and RBIs with 129. Trea Turner is another important player for the Phillies. He has played in 140 games and has a batting average of .305. Turner has hit 15 home runs and scored 94 runs this season. Ranger Suárez will be the starting pitcher for the Phillies. He has an ERA of 2.84 and a WHIP of 1.17. Suárez’s record stands at 12 wins and 6 losses.

Final Betting Pick

The Phillies have a solid road record this season, standing at 41-39. This gives them confidence when playing away from home. Ranger Suárez has been a reliable starting pitcher for them, with an ERA of 2.84. His strong performance on the mound increases the chances of a Phillies win.

The over 9.0 runs prediction seems likely with both teams having capable hitters. The Phillies have shown they can score, with players like Kyle Schwarber hitting 53 home runs. Eduardo Rodriguez’s 5.12 ERA suggests the Diamondbacks might allow several runs. This combination makes a high-scoring game a reasonable expectation.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.