The Pittsburgh Pirates will visit the Baltimore Orioles on Wednesday, September 10, 2025. The game will take place at Oriole Park at Camden Yards in Baltimore, MD, starting at 6:35 PM. Fans can catch the action on MASN, with the weather expected to be mild and overcast.

Pirates vs. Orioles Betting Prediction

• Money Line Prediction: Orioles +129. The Orioles have a better recent record, going 7-3 in their last 10 games. They also won the last game against the Pirates, showing strong home performance.
• Over/Under Prediction: Under 7.5 (-118). Both teams have shown lower-scoring games recently, with the last game ending 3-2. The starting pitchers have solid ERAs, suggesting a low-scoring game.

Team Trends

• The Pittsburgh Pirates have a road record of 22-48 this season.
• The Baltimore Orioles have a home record of 34-38 this season.
• The Orioles won their last game against the Pirates 3-2 on September 9, 2025.
• The Pirates are currently on a 4-game losing streak.
• The Orioles have won 7 of their last 10 games.

Pirates vs Orioles Preview

The Pittsburgh Pirates will take on the Baltimore Orioles at Oriole Park. The Pirates are looking to break their 4-game losing streak. They have a record of 64-81 and sit in the 5th spot in their division. Meanwhile, the Orioles hold a record of 67-77 and also rank 5th in their division. They have been stronger lately, winning 7 of their last 10 games.

On the mound for the Pirates is Paul Skenes. He has a strong ERA of 1.98 and a WHIP of 0.94. Skenes has a season record of 10-9. The Orioles will counter with Tyler Wells. Wells has an ERA of 3.60 and a WHIP of 1.00. He has a record of 1-0 this season. The game starts at 6:35 PM, and fans can watch on MASN.

Baltimore Orioles: Key Players and Stats

Gunnar Henderson is a standout for the Orioles. He has played in 136 games with a batting average of .272. Henderson has hit 16 home runs and scored 80 runs, leading the team in runs and RBIs. Jackson Holliday is another key player. He has appeared in 134 games, maintaining a batting average of .250. Holliday has hit 17 home runs, ranking first on the team in that category. Tyler Wells is set to start on the mound for the Orioles. His ERA is 3.60, and he has a WHIP of 1.00. Wells has a record of 1-0 this season.

Pittsburgh Pirates: Players and Pitching Insights

Andrew McCutchen stands out for the Pirates. He has played in 123 games with a batting average of .243. McCutchen leads the team with 13 home runs and 53 RBIs. Spencer Horwitz has contributed in 92 games. He holds a batting average of .257 and has hit 7 home runs. Horwitz has also scored 44 runs this season. Paul Skenes will start on the mound for the Pirates. His ERA is 1.98, and he has a WHIP of 0.94. Skenes has a record of 10-9 this season.

Final Betting Pick

The Orioles have a strong recent record, winning 7 of their last 10 games. They also have a better home record compared to the Pirates’ road record. This makes the Orioles a good pick for the money line at +129. The Pirates struggle on the road with a 22-48 record, which adds to the Orioles’ advantage in this game. For the over/under prediction, choosing under 7.5 makes sense. Both teams have shown lower-scoring games recently, including the last game that ended 3-2. The starting pitchers, Paul Skenes and Tyler Wells, have solid ERAs of 1.98 and 3.60, respectively. This suggests a low-scoring game, supporting the under prediction.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.