San Diego Padres vs Chicago Cubs MLB Betting Prediction
PublishedSeptember 30, 2025,            Posted By: Maria Uebelhor
Last updated:September 30, 2025 ,

MLB San Diego Padres vs Chicago Cubs Prediction 9/30

The San Diego Padres will play against the Chicago Cubs on Tuesday, September 30, 2025. The game will take place at Wrigley Field in Chicago, IL, and is set to start at 3:08 PM. Fans can catch the action on ABC, with weather conditions expected to be clear and mild.

Padres vs. Cubs Betting Prediction

  • Money Line Prediction: San Diego Padres at -103. The Padres have a strong pitcher in Nick Pivetta, who has a lower ERA and WHIP compared to the Cubs’ Matthew Boyd. This gives the Padres an edge in pitching for this game.
  • Over/Under Prediction: Under 7.0 (-112). Both teams have solid starting pitchers with low ERAs, suggesting a low-scoring game. The Cubs also have a strong home record, which may limit the Padres’ scoring opportunities.

Team Trends

  • The Padres finished the regular season with a 90-72 record, placing them 3 games behind in the NL West.
  • On the road, the Padres had a 38-43 record this season.
  • The Cubs ended their season with a 92-70 record, 5 games behind in the NL Central.
  • The Cubs had a strong home record of 50-31 this season.
  • The game will be played at Wrigley Field with clear skies and a light breeze.

Padres vs Cubs Preview

The San Diego Padres and Chicago Cubs are set to play at Wrigley Field on September 30, 2025. Both teams are starting the season with a clean slate, each holding a 0-0 record. This game marks the beginning of a new chapter for both teams as they aim to establish dominance early in the season.

Nick Pivetta will take the mound for the Padres. He finished last season with a solid 2.87 ERA and a 13-5 record. The Cubs will counter with Matthew Boyd, who posted a 3.21 ERA and a 14-8 record. With these talented pitchers, fans can expect a competitive game. The weather is clear, making it a perfect day for baseball at the iconic Wrigley Field.

Chicago Cubs: Power at the Plate

The Cubs have some strong hitters this season. Michael Busch leads the team with 34 home runs, ranking 12th in the league. Seiya Suzuki is right behind him with 32 home runs, placing him 13th. Nico Hoerner stands out with a .297 batting average, which is the best on the team. His on-base percentage is also impressive at .345. This makes him a key player for getting on base and scoring runs. Matthew Boyd will start on the mound for the Cubs. His record is 14-8 with an ERA of 3.21. Boyd’s WHIP of 1.09 shows he can control the game and keep runners off base.

San Diego Padres: Consistent Performers

Manny Machado is a key player for the Padres. He has hit 27 home runs and has 95 RBIs. His batting average is .275, and he leads the team in runs scored with 91. Luis Arraez is another important hitter for the team. He has a batting average of .292, which is the highest on the team. Ryan O’Hearn also contributes with a .281 average and 17 home runs. Nick Pivetta will start as the pitcher for the Padres. His ERA is 2.87, and his WHIP is 0.98. He has a record of 13-5, showing his ability to control games effectively.

Final Betting Pick

The Padres are a good pick for the money line at -103. Nick Pivetta’s strong pitching stats, including a 2.87 ERA and 0.98 WHIP, give them an advantage. The Padres have also shown they can perform well on the road, with a record of 38-43.

The under 7.0 prediction is reasonable due to both teams having strong starting pitchers. Matthew Boyd of the Cubs has a 3.21 ERA, which suggests a low-scoring game. The Cubs’ solid home record of 50-31 could also limit the Padres’ scoring chances, keeping the total score low.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.