On Friday, September 26, 2025, the St. Louis Cardinals will play against the Chicago Cubs at Wrigley Field. The game starts at 2:20 PM and will be broadcast on MLBN. Expect a mild day with a light breeze under clear skies as the Cardinals, with a record of 78-81, take on the Cubs, who stand at 89-70.

Cardinals vs. Cubs Betting Prediction

• Money Line Prediction: St. Louis Cardinals +145. The Cardinals have won 6 of their last 10 games, showing better recent form than the Cubs, who have lost 6 of their last 10.
• Over/Under Prediction: Over 9.0 (-101). Both teams have shown the ability to score runs, with the Cardinals scoring 9 in a recent game and the Cubs putting up 10 in another.

Team Trends

• The St. Louis Cardinals have a road record of 34-44 this season.
• The Chicago Cubs hold a home record of 47-31 this season.
• The Cardinals recently lost to the San Francisco Giants with a score of 4-3.
• The Cubs’ last game was a loss to the New York Mets, ending 8-5.
• The Cardinals are ranked 4th in the NL Central Division, while the Cubs are ranked 2nd.

Cardinals vs Cubs Preview

The St. Louis Cardinals will travel to Chicago to play the Cubs at Wrigley Field. The Cardinals have a 78-81 record and are ranked fourth in their division. They have won six of their last ten games but lost their most recent game. Miles Mikolas will start for the Cardinals, bringing an ERA of 4.76 and a WHIP of 1.33.

The Cubs, with an 89-70 record, are second in their division. They have lost six of their last ten games, including their last one. Colin Rea will take the mound for the Cubs, sporting an ERA of 4.10 and a WHIP of 1.27. Fans can expect a mild day with a light breeze under clear skies for this afternoon game. Tune in to MLBN to catch the action.

Chicago Cubs: A Look at the Top Performers

The Chicago Cubs have some strong hitters leading their lineup. Michael Busch has played 152 games, hitting 31 home runs, which ranks 13th in the league and 1st on the team. Seiya Suzuki is another key player, with 29 home runs in 148 games, ranking 15th in the league. Nico Hoerner stands out with a batting average of .299 over 153 games. He leads the team in runs with 87, placing him 23rd in the league. Dansby Swanson also contributes with 24 home runs and 83 runs scored in 156 games. Pitching is crucial for the Cubs, with Colin Rea starting against the Cardinals. Rea has a 4.10 ERA and a 10-7 win-loss record. The team’s overall ERA is 3.85, ranking 9th in the league.

St. Louis Cardinals: Key Players and Pitching Insights

Willson Contreras is a leader for the St. Louis Cardinals. He has played 135 games, hitting 20 home runs. Contreras also has a batting average of .257 and has scored 70 runs. Alec Burleson adds strength to the team. He has a batting average of .293 over 137 games. Burleson has hit 18 home runs and scored 54 runs. On the mound, Miles Mikolas will start for the Cardinals. Mikolas has an ERA of 4.76 and a win-loss record of 8-10. The Cardinals’ team ERA is 4.24, placing them 20th in the league.

Final Betting Pick

The Cardinals are a solid pick for the money line at +145. They have won 6 of their last 10 games, showing they can perform well on the road. Their recent win against the Giants, where they scored 9 runs, highlights their offensive potential.

Choosing the over 9.0 runs also seems wise. Both teams have shown they can score, with the Cubs recently scoring 10 against the Mets. The Cubs’ pitching has given up 200 home runs this season, which could lead to a high-scoring game. The Cardinals’ ability to hit extra-base hits in recent games adds to the likelihood of a high total.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.