St. Louis Cardinals vs Chicago Cubs MLB Betting Prediction
PublishedSeptember 27, 2025,            Posted By: Maria Uebelhor
Last updated:September 27, 2025 ,

MLB St. Louis Cardinals vs Chicago Cubs Prediction 9/27

The St. Louis Cardinals will take on the Chicago Cubs on Saturday, September 27, 2025, at Wrigley Field. The Cardinals hold a record of 78-82 and are ranked fourth in the NL Central. The Cubs have a 90-70 record and sit in second place in the division. The game will start at 2:20 PM, and fans can expect clear skies with a light breeze. Tune in to FDSMW for the live broadcast.

Cardinals vs. Cubs Betting Prediction

  • Money Line Prediction: Cubs -171. The Cubs have a strong home record of 48-31 and recently defeated the Cardinals 12-1. With Jameson Taillon’s solid pitching stats, they have an edge.
  • Over/Under Prediction: Over 9.5 (-102). Both teams have shown the ability to score, with the Cubs recently putting up 12 runs against the Cardinals. The Cardinals have also had high-scoring games recently.

Team Trends

  • The St. Louis Cardinals have a road record of 34-45 this season.
  • The Chicago Cubs have a home record of 48-31 this season.
  • In their last game, the Chicago Cubs defeated the St. Louis Cardinals 12-1.
  • The St. Louis Cardinals are on a two-game losing streak.
  • The Chicago Cubs are ranked 2nd in the NL Central Division.

Cardinals vs Cubs Preview

The St. Louis Cardinals and the Chicago Cubs will meet at Wrigley Field on Saturday. The Cardinals, with a record of 78-82, are looking to end their two-game losing streak. Michael McGreevy will be on the mound for St. Louis. He has an ERA of 4.35 and a WHIP of 1.23 this season.

The Cubs have a 90-70 record and are second in the NL Central. They aim to build on their recent win. Jameson Taillon will start for Chicago, bringing an ERA of 3.78 and a WHIP of 1.07. The game will begin at 2:20 PM, and the weather is expected to be clear and mild.

Chicago Cubs: Home Field Highlights

The Chicago Cubs have a solid lineup this season. Michael Busch leads the team with 32 home runs, ranking 12th in the league. Seiya Suzuki follows closely with 30 home runs and tops the team with 101 RBIs. Nico Hoerner is a key player for the Cubs. He holds a batting average of .300, the highest on the team. Hoerner also leads in runs scored with 89, making him a vital part of the offense. On the mound, Jameson Taillon is the starting pitcher for the Cubs. He has a 3.78 ERA and a 10-7 record this season. Taillon’s WHIP of 1.07 shows his ability to keep runners off base.

St. Louis Cardinals: Road Challenges

The St. Louis Cardinals have some strong hitters this season. Willson Contreras leads the team with 20 home runs and 80 RBIs. Alec Burleson follows with 18 home runs and a .292 batting average. Iván Herrera is another key player for the Cardinals. He has a batting average of .287 and has hit 19 home runs. Brendan Donovan adds depth with 10 home runs and a .287 average. On the pitching side, Michael McGreevy will start for the Cardinals. He has an ERA of 4.35 and a WHIP of 1.23. McGreevy’s record stands at 8-3 this season.

Final Betting Pick

The Cubs’ money line at -171 looks promising due to their strong home record of 48-31. Their recent 12-1 win over the Cardinals shows their ability to dominate at Wrigley Field. Jameson Taillon’s solid stats with a 3.78 ERA and 1.07 WHIP give the Cubs an advantage in pitching.

The over 9.5 total is a good pick because both teams have shown they can score. The Cubs scored 12 runs in their last game against the Cardinals, while the Cardinals have had high-scoring games recently. With hitters like Seiya Suzuki and Michael Busch, the Cubs can contribute to a high-scoring game.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.