The St. Louis Cardinals will take on the Chicago Cubs on Sunday, September 28, 2025, at Wrigley Field. The Cardinals come into the game with a 78-83 record, while the Cubs hold a 91-70 record. Game time is set for 3:20 PM, and fans can expect a mild day with clear skies. The game will be broadcast on FDSMW.

Cardinals vs. Cubs Betting Prediction

• Money Line Prediction: Chicago Cubs -168. The Cubs have a strong home record of 49-31 and are on a 2-game winning streak. The Cardinals have struggled on the road with a 34-46 record.
• Over/Under Prediction: Over 8.0. Both teams have shown the ability to score runs recently, with the Cubs scoring 19 runs in their last two games against the Cardinals.

Team Trends

• The St. Louis Cardinals have a road record of 34-46 this season.
• The Chicago Cubs have a home record of 49-31 this season.
• In their last game, the Cubs won 7-3 against the Cardinals.
• The Cardinals have lost their last three games.
• The Cubs are currently on a two-game winning streak.

Cardinals vs Cubs Preview

The St. Louis Cardinals and Chicago Cubs are set for an exciting game at Wrigley Field. The Cardinals, with a 78-83 record, are looking to end their three-game losing streak. Kyle Leahy will take the mound for the Cardinals. He has a solid ERA of 3.18 and a WHIP of 1.26, which gives them hope for a strong performance.

The Chicago Cubs, holding a 91-70 record, are aiming to extend their two-game winning streak. Javier Assad will be their starting pitcher. Assad has an ERA of 4.26 and a WHIP of 1.29. The Cubs have had a mixed last ten games, going 4-6, but the home crowd at Wrigley Field will be cheering them on.

Chicago Cubs: A Look at the Key Players and Stats

The Chicago Cubs have some strong hitters this season. Michael Busch leads the team with 34 home runs. Seiya Suzuki is close behind with 31 home runs and leads the team with 102 RBIs. Nico Hoerner stands out with a .297 batting average, the highest on the team. His on-base percentage is .346. This makes him a key player in getting on base and scoring runs. Javier Assad is the starting pitcher for the Cubs in this game. His ERA is 4.26, and his WHIP is 1.29. With a record of 3-1, he looks to keep the Cubs in a good position.

St. Louis Cardinals: Key Players and Game Outlook

The St. Louis Cardinals have some solid hitters on their team. Willson Contreras leads the team with 20 home runs. Alec Burleson follows with 18 home runs and a .290 batting average. Iván Herrera also contributes with 19 home runs and a .286 batting average. In the upcoming game, Kyle Leahy will start as the pitcher for the Cardinals. He has an ERA of 3.18 and a WHIP of 1.26. His record is 4-2, showing he can keep the team competitive. The Cardinals have a team batting average of .245, ranked 12th in the league. Their on-base percentage is .313, placing them 15th. With 148 home runs, they rank 27th, but they have 262 doubles, ranking 9th.

Final Betting Pick

The Cubs have a strong home record, which makes the money line prediction of -168 a good choice. They have won 49 games at Wrigley Field this season. This gives them confidence playing at home. The Cardinals have struggled on the road, with a 34-46 record. This makes it hard for them to win away from Busch Stadium.

The over 8.0 prediction is supported by recent high-scoring games between these teams. The Cubs scored 19 runs in their last two games against the Cardinals. This shows their ability to score runs. The Cardinals also have hitters like Willson Contreras and Alec Burleson who can contribute to the score. This makes the over 8.0 a solid pick for this game.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.