Chicago White Sox vs Washington Nationals MLB Betting Prediction

MLB White Sox vs Washington Nationals Prediction 9/28

The Chicago White Sox will play against the Washington Nationals on Sunday, September 28, 2025. The game will take place at Nationals Park in Washington, DC, starting at 3:05 PM. Fans can watch the game on MASN, with weather forecasts predicting a mild day and broken clouds.

White Sox vs. Nationals Betting Prediction

  • Money Line Prediction: Washington Nationals -118. The Nationals have a better recent record, winning 4 of their last 10 games, and they play at home where they have a slight edge.
  • Over/Under Prediction: Over 8.5 (-120). Both teams have shown they can score, with recent games going over this total, including a 10-9 game two days ago.

Team Trends

  • The Chicago White Sox have a road record of 26-54 this season.
  • The Washington Nationals have a home record of 32-48 this season.
  • In their last game, the Washington Nationals won against the Chicago White Sox 6-5.
  • The Chicago White Sox have lost 8 of their last 10 games.
  • The Washington Nationals have won 4 of their last 10 games.

White Sox vs Nationals Preview

The Chicago White Sox head to Nationals Park to play the Washington Nationals on Sunday. The White Sox have struggled this season, holding a record of 59-102 and sitting last in their division. In their last ten games, they have only managed two wins.

The Nationals come into this game with a 66-95 record, also in last place in their division. They have done slightly better in their recent games, winning four of their last ten. On the mound for the White Sox is Shane Smith, who has a 3.98 ERA and a 6-8 record. Brad Lord will pitch for the Nationals, carrying a 4.12 ERA and a 5-9 record.

Washington Nationals: Key Players and Stats

The Washington Nationals have some notable hitters in their lineup. CJ Abrams, the shortstop, has played 143 games with a batting average of .258. He leads the team in runs with 92, ranking 19th in the league. Luis García Jr. plays second base and has participated in 138 games. He has a batting average of .254 and leads the team with 66 RBIs. Josh Bell, the first baseman, has hit 22 home runs, the most on the team. The Nationals’ team batting average is .243, placing them 13th in the league. They have hit 161 home runs, ranking 22nd. In pitching, Brad Lord will start with an ERA of 4.12.

Chicago White Sox: Key Players and Performance

The Chicago White Sox have some strong hitters in their lineup. Lenyn Sosa stands out with 22 home runs and a .263 batting average. Miguel Vargas leads the team with 79 runs in 138 games. Chase Meidroth contributes with a .256 batting average and 23 RBIs. Colson Montgomery has hit 21 home runs in 70 games. Edgar Quero adds to the team with a .271 batting average. Shane Smith will start on the mound for the White Sox. He has an ERA of 3.98 and a WHIP of 1.24. His record this season is 6 wins and 8 losses.

Final Betting Pick

The Washington Nationals are favored on the money line at -118. They have won 4 of their last 10 games, which gives them a slight edge over the Chicago White Sox. Playing at home, the Nationals have a record of 32-48, which might not seem strong, but it is better than the White Sox’s road record of 26-54. This home field advantage could be a key factor in their favor.

For the over/under, the prediction is over 8.5 runs at -120. Both teams have shown they can score, with recent games going over this total. In their last game, the Nationals won 6-5, and two days ago, they played a high-scoring game that ended 10-9. This suggests that both teams’ offenses are capable of putting up runs, making the over a reasonable pick.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.