On Monday, December 22, 2025, the #18 Illinois Fighting Illini will take on the Missouri Tigers at 8:00 PM ET. The game will be held at the Enterprise Center in St. Louis, MO, a neutral site. Illinois, from the Big Ten, is favored with a spread of -8.5, while the Southeastern Conference’s Missouri Tigers are the underdogs with a spread of +8.5. Fans can catch all the action on FS1.

Illinois vs. Missouri Betting Prediction

• Spread Prediction: Missouri +8.5 (-110). Missouri has a strong record at 10-2 and performs well at home. They might keep the game close against Illinois.
• Over/Under Prediction: Under 155.5 (-113). Both teams have been hitting the under more often, with Illinois at 4-7 and Missouri at 5-7 for the season.

Team Trends

• The Illinois Fighting Illini are favored by 8.5 points in their game against the Missouri Tigers.
• Illinois has a straight-up record of 8-3 in all games this season.
• Missouri has won 10 out of 12 games straight up this season.
• The game will be played at a neutral site in St. Louis, Missouri.
• The over/under for the game is set at 155.5 points.

Illinois vs Missouri Preview

The Illinois Fighting Illini and Missouri Tigers are set to meet on December 22, 2025. The game will take place at the Enterprise Center in St. Louis, a neutral site. Illinois holds a record of 8-3 and is ranked #18 in the nation. They recently lost to Nebraska by 3 points but had wins against Ohio State and Tennessee. Key players like Keaton Wagler and Kylan Boswell have been strong for Illinois.

Missouri comes into this game with a 10-2 record. They have been solid at home, winning 9 out of 10 games. Missouri’s recent games include a win against Bethune-Cookman and Alabama State, but they fell to Kansas. Players like Anthony Robinson II and Mark Mitchell have been leading the way for the Tigers. This non-conference matchup will be broadcast on FS1. Illinois is favored by 8.5 points.

Missouri Tigers: A Strong Home Record

The Missouri Tigers are part of the Southeastern Conference. They hold a 10-2 record in the 2026 regular season. At home, they have been strong, winning 9 out of 10 games. In recent games, the Tigers have shown their scoring ability. They won against Bethune-Cookman with a score of 82-60. Against Alabama State, they secured a win with a score of 85-77. Player performances have been key for Missouri. Mark Mitchell leads the team with an average of 18.2 points per game. Jacob Crews and Anthony Robinson II also contribute significantly to the team’s success.

Illinois Fighting Illini: Aiming for Another Win

The Illinois Fighting Illini are ranked 18th in the AP poll. They have an 8-3 record this season. On the road, they have won 2 out of 3 games. In their recent game against Nebraska, Illinois lost by 3 points. Keaton Wagler and Andrej Stojakovic each scored 19 points. Kylan Boswell added 20 points to the team’s total. Illinois scores an average of 87.8 points per game. Their field goal percentage is 47.8%. Kylan Boswell leads the team with 16.1 points per game.

Final Betting Pick

Missouri getting +8.5 points is a solid pick. They have a strong 10-2 record and perform well at home, even though this game is at a neutral site. Their ability to keep games close makes them a good choice against Illinois, who is favored but not unbeatable.

Choosing the under 155.5 points also makes sense. Illinois and Missouri have both been hitting the under more often this season. With Illinois at 4-7 and Missouri at 5-7 for the season, the trend suggests a lower-scoring game is likely.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.