The Arizona Wildcats will take on the Iowa State Cyclones in Week 5 of the 2025 regular season. The game is scheduled for Saturday, September 27, 2025, at 7:00 PM. It will be held at Jack Trice Stadium in Ames, IA, and will air on ESPN.

Arizona vs. Iowa State Betting Prediction

• Money Line Prediction: Iowa State Cyclones -225. Iowa State has a strong home record of 3-0 this season. They are ranked 14th in the AP poll, showing their strength.
• Over/Under Prediction: Under 49.5. Both teams have solid defenses, with Iowa State allowing only 57 points this season and Arizona allowing just 26.

Team Trends

• The Arizona Wildcats have a 3-0 record this season, but they have not played any road games yet.
• Iowa State Cyclones are ranked #14 in the AP Poll and #13 in the Coaches Poll.
• Arizona Wildcats’ defense is strong, allowing only 26 points this season, ranking 6th nationally.
• Iowa State Cyclones have a perfect 3-0 home record this season.
• The game will be held at Jack Trice Stadium in Ames, IA, and will be broadcast on ESPN.

Arizona vs Iowa State Preview

The Arizona Wildcats are heading into Week 5 with a perfect 3-0 record. They have shown strength at home but will face their first road test of the season against Iowa State. Arizona is part of the Big 12 Conference and is currently on a three-game win streak. They are looking to make a mark against a ranked opponent.

Iowa State Cyclones are off to a strong start with a 4-0 record. They are ranked 14th in the AP Poll and 13th in the Coaches Poll. The Cyclones have been solid at home with a 3-0 record at Jack Trice Stadium. They aim to continue their winning streak and maintain their high standing in the Big 12 Conference.

Iowa State Cyclones: Season Overview

The Iowa State Cyclones are having a strong season. They hold a 4-0 record, with a perfect 3-0 at home. Their recent win was a 24–16 game against Arkansas State.

The Cyclones play in the Big 12 Conference and rank #14 in the AP Poll. They also rank #13 in the Coaches Poll. Their home stadium is Jack Trice Stadium.

Key players for Iowa State include Rocco Becht, who leads the team with 860 passing yards and 7 touchdowns. Abu Sama III contributes with 182 rushing yards and 2 touchdowns. Benjamin Brahmer has 109 receiving yards and 3 touchdowns.

Arizona Wildcats: Road Warriors Ready for Action

The Arizona Wildcats enter the game with a 3-0 season record. They have yet to play a road game this season. Their last game was a 23–17 win over Kansas State.

Arizona’s quarterback, Noah Fifita, has thrown for 712 yards and 6 touchdowns in three games. Ismail Mahdi leads the rushing attack with 263 yards and 1 touchdown. Javin Whatley is the top receiver with 237 receiving yards and 2 touchdowns.

Defensively, Arizona has allowed only 26 points this season, ranking them 6th. They have recorded 8 sacks and 5 interceptions, both in the top 10 rankings. They also recovered 3 fumbles, placing them 3rd in that category.

Final Betting Pick

Iowa State is a strong pick for the money line at -225. They have a perfect home record of 3-0 this season. Their #14 ranking in the AP poll shows their strength and consistency. Playing at Jack Trice Stadium gives them an edge, as they have won 9 of their last 10 home games.

The prediction for the total points to be under 49.5 is based on both teams’ defenses. Iowa State has allowed only 57 points this season, while Arizona has allowed just 26. This indicates a low-scoring game. Both teams focus on defense, making the under a solid choice.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.