BYU Cougars vs Colorado Buffaloes NCAAF Betting Prediction
PublishedSeptember 23, 2025,            Posted By: Maria Uebelhor
Last updated:September 23, 2025 ,

NCAAF BYU Cougars vs Colorado Buffaloes Prediction 9/27

In Week 5 of the 2025 regular season, the BYU Cougars will play against the Colorado Buffaloes. The game is set for Saturday, September 27, 2025, at 10:15 PM. It will take place at Folsom Field in Boulder, CO, and will be broadcast on ESPN. This night game will see BYU, ranked #25 in the AP Poll, bring their 3-0 record to face Colorado, who holds a 2-2 record this season.

BYU vs. Colorado Betting Prediction

  • Money Line Prediction: BYU Cougars -242. BYU has a strong record of 3-0 this season and has shown consistency in winning games, especially as favorites. They also defeated Colorado in their last postseason meeting.
  • Over/Under Prediction: Over 47.0. Both teams have shown the ability to score, with BYU scoring 34 in their last game and Colorado putting up 37. This suggests the total could exceed 47 points.

Team Trends

  • BYU Cougars are ranked #25 in the AP Poll and #24 in the Coaches Poll.
  • Colorado Buffaloes have a home record of 2-1 this season.
  • BYU Cougars have not lost a game this season, holding a 3-0 record.
  • In their last postseason game, BYU Cougars defeated Colorado Buffaloes 36-14 in the Valero Alamo Bowl.
  • BYU Cougars’ defense is ranked 1st in points against, allowing only 16 points this season.

BYU vs Colorado Preview

The BYU Cougars are heading into Week 5 with a perfect 3-0 record. They are ranked #25 in the AP Poll and #24 in the Coaches Poll. BYU has shown strong performances both at home and on the road. This game against Colorado will be their first conference game of the season. BYU recently defeated the Buffaloes in the Valero Alamo Bowl, so they will look to continue their success against them.

On the other side, the Colorado Buffaloes have a 2-2 record. They are unranked but have managed to secure two wins at home this season. Colorado is coming off a win and will try to use their home advantage at Folsom Field. The Buffaloes will aim to improve their standing in the Big 12 with a victory over a ranked opponent like BYU.

Colorado Buffaloes: Key Players and Team Overview

The Colorado Buffaloes are part of the Big 12 Conference and play at Folsom Field. This season, the team has a record of 2-2 with a home record of 2-1. In their last postseason game, they faced BYU Cougars at the Valero Alamo Bowl and were defeated 36-14.

Kaidon Salter leads the quarterbacks with 565 passing yards and four touchdowns in three games. Ryan Staub follows with 361 passing yards and three touchdowns in two games. The running back position sees DeKalon Taylor with 83 rushing yards, while Simeon Price leads with 144 rushing yards and two touchdowns.

The team’s offense has accumulated 934 passing yards and 570 rushing yards this season. On defense, they have given up 90 points and recorded seven sacks, ranking them 11th in the country for sacks. The Buffaloes have also recovered three fumbles and intercepted two passes, ranking third nationally in both categories.

BYU Cougars: Season Highlights and Star Players

The BYU Cougars are in the Big 12 Conference and have an impressive record of 3-0 this season. They play their home games at LaVell Edwards Stadium. In their most recent game, they won 34-13 against East Carolina.

Bear Bachmeier leads the quarterbacks with 518 passing yards and four touchdowns over three games. LJ Martin is the top running back with 342 rushing yards and one touchdown. On the receiving end, Chase Roberts has caught 11 passes for 185 yards and a touchdown.

In defense, BYU has allowed only 16 points, ranking them first in the nation. They’ve also recorded seven sacks and four interceptions. Their strong defense makes them a tough opponent for any team.

Final Betting Pick

BYU’s strong start to the season makes them a solid pick for the money line. They have a 3-0 record, showing they know how to win. Their recent victory over East Carolina by 34-13 shows they can perform well on the road. BYU’s past success against Colorado in the postseason also gives them an edge.

The over 47.0 prediction seems reasonable given both teams’ scoring abilities. BYU scored 34 points in their last game, while Colorado put up 37 against Wyoming. With both teams having offenses that can score, the total points could easily surpass 47. This makes the over a good choice for this game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.