The Colorado Buffaloes will take on the Houston Cougars on Friday, September 12, 2025. This Week 3 game of the 2025 Regular Season will be held at TDECU Stadium in Houston, TX. The game will start at 7:30 PM and will be broadcast on ESPN.

Colorado vs. Houston Betting Prediction

• Money Line Prediction: Houston -225. Houston has a strong record at home this season with a 1-0 record. They are also undefeated overall, making them a reliable pick.
• Over/Under Prediction: Under 43.5 (-108). Both teams have shown strong defensive performances this season. Houston has allowed only 9 points in total, which suggests a lower-scoring game.

Team Trends

• The Houston Cougars have a perfect 2-0 record this season, winning both home and away games.
• The Colorado Buffaloes are 1-1 this season but have not yet played an away game.
• In their last home game, the Houston Cougars defeated Stephen F. Austin Lumberjacks 27-0.
• The Colorado Buffaloes won their last game against Delaware Fightin’ Blue Hens with a score of 31-7.
• Houston’s defense has allowed only 9 points this season, ranking 3rd in the league.

Colorado vs Houston Preview

The Colorado Buffaloes are set to play their first road game of the season against the Houston Cougars. The Buffaloes hold a 1-1 record and are coming off a win. They are looking to improve their standing in the Big 12 Conference. With no conference games played yet, this game gives them a chance to gain momentum.

The Houston Cougars are undefeated with a 2-0 record. They have already secured a home victory this season and are on a two-game win streak. Both teams are part of the Big 12 Conference, but have not played any conference games this season. The Cougars aim to continue their winning streak and maintain their strong start to the season at home.

Houston Cougars: Early Season Success

The Houston Cougars are off to a strong start in the Big 12 with a 2-0 record. They have played one game at their home, TDECU Stadium, and one on the road, winning both. Their conference record is still at 0-0, as they have not yet faced a conference opponent.

Quarterback Conner Weigman has been a key player for the Cougars. He has passed for 347 yards and four touchdowns in two games. Running back Dean Connors has also contributed with 182 rushing yards and two touchdowns in two games.

On the defensive side, the Cougars have allowed only nine points, ranking them third in points against. They have also recorded five sacks and three interceptions, showing a strong defensive presence. With these performances, the team looks ready to tackle the challenges of the season.

Colorado Buffaloes: Ready for the Road

The Colorado Buffaloes have a 1-1 record this season. They have played both games at home, winning one and losing one. Their conference record is still 0-0.

Kaidon Salter, the quarterback, has passed for 261 yards and has one passing touchdown. Ryan Staub has also contributed with 157 passing yards and two touchdowns in one game. Running back Micah Welch has added 78 rushing yards and one rushing touchdown in two games.

On the defensive side, the Buffaloes have given up 34 points, placing them 25th in points against. They have also recorded three sacks and two interceptions. The team has recovered four fumbles, ranking second in this category.

Final Betting Pick

Houston is a strong pick for the money line at -225. They have a perfect record this season, including a win at home. Their defense has been tough, allowing only 9 points in two games. This makes them a reliable choice against Colorado, who have not played an away game yet.

The under 43.5 prediction is based on both teams’ strong defenses. Houston’s defense has been solid, ranking third in points against. Colorado’s defense is also strong, ranking 25th in points against. With both teams focused on defense, a lower-scoring game is likely.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.