The Duke Blue Devils are set to play against the Syracuse Orange on Saturday, September 27, 2025. This game will take place at the JMA Wireless Dome in Syracuse, NY. Kickoff is scheduled for 12:00 PM and will be broadcast on ACCN. Duke comes into this game with a 2-2 record, while Syracuse holds a 3-1 record this season. Both teams are part of the Atlantic Coast Conference.

Duke vs. Syracuse Betting Prediction

• Money Line Prediction: Syracuse Orange +172. Syracuse has a strong home record this season at 2-1, and they recently won against Clemson. They have been solid at home, making them a good value pick.
• Over/Under Prediction: Over 60.5 (-108). Both teams have shown high-scoring games recently. Duke has gone over in their last four games, and Syracuse has a trend of high-scoring games, especially at home.

Team Trends

• Duke has a road record of 0-1 this season.
• Syracuse has a home record of 2-1 this season.
• Duke’s passing offense ranks 6th in the nation with 1,327 yards.
• Syracuse’s passing offense ranks 2nd in the nation with 1,416 yards.
• Duke’s defense has recorded 10 sacks, ranking them 8th in the nation.

Duke vs Syracuse Preview

The Duke Blue Devils will travel to face the Syracuse Orange in Week 5 of the 2025 season. Duke has a 2-2 record and is looking to improve on the road, where they are currently 0-1. They are coming off a win and hope to carry that momentum into this game. Their conference record stands at 1-0, showing they can compete in the Atlantic Coast Conference.

Syracuse, with a 3-1 record, has been strong at home with a 2-1 record. They are on a three-game win streak and hold a conference record of 1-0. The Orange are ranked 2nd in their conference, indicating their strong start. Playing at the JMA Wireless Dome gives them a home-field advantage, which they will aim to use against Duke.

Syracuse Orange Season Overview

The Syracuse Orange play in the Atlantic Coast Conference. Their home games take place at the JMA Wireless Dome. This season, Syracuse holds a 3-1 record with a 2-1 mark at home.

On offense, Syracuse has scored 153 points, ranking 16th. They have 1,416 passing yards, placing them 2nd overall. Rushing yards total 479, putting them 95th in that category.

In their last postseason game, Syracuse won against the Washington State Cougars with a score of 52-35. This victory took place in the DirecTV Holiday Bowl on December 27, 2024. Syracuse’s conference record for this season is 1-0.

Duke Blue Devils in Action

The Duke Blue Devils play in the Atlantic Coast Conference. Their home games are held at Wallace Wade Stadium. This season, Duke’s record stands at 2-2 with a road record of 0-1. In their last postseason game, Duke fell to the Ole Miss Rebels, 52-20, in the TaxSlayer Gator Bowl.

Quarterback Darian Mensah is a key player for Duke. He has thrown for 1,305 yards this season, ranking 3rd in the league. Mensah has 11 passing touchdowns and 2 interceptions. In the running game, Anderson Castle leads with 193 rushing yards.

Duke has scored 136 points this season, ranking 27th in points for. Their passing yards are 1,327, placing them 6th overall. On defense, Duke has given up 129 points, ranking 89th. They have recorded 10 sacks, which ranks 8th in the league.

Final Betting Pick

Syracuse has a strong home record this season, winning two out of three games at the JMA Wireless Dome. Their recent victory against Clemson shows they can perform well against tough teams. With a moneyline of +172, Syracuse offers good value for those looking to bet on them at home.

The over/under prediction of over 60.5 is supported by both teams’ recent performances. Duke has gone over in their last four games, showing they can score and allow points. Syracuse also has a trend of high-scoring games, especially at home, where they scored 66 points against Colgate. This makes the over a strong pick for this game.

Action 24/7 isn’t just another sportsbook — we’re a locally owned and operated sportsbook in Tennessee. From Nashville to Knoxville, we’re built for Tennessee fans, by Tennessee fans. Bet local, support local, and enjoy a world-class sportsbook experience without leaving home with Action 24/7.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.