Indiana Hoosiers vs Purdue Boilermakers NCAAF Betting Prediction
PublishedNovember 25, 2025,            Posted By: Maria Uebelhor
Last updated:November 25, 2025 ,

NCAAF Indiana Hoosiers vs Purdue Prediction 11/28

On Friday, November 28, 2025, the Indiana Hoosiers will take on the Purdue Boilermakers at Ross-Ade Stadium in West Lafayette, IN. This Week 14 game of the 2025 regular season kicks off at 7:30 PM and will be broadcast on NBC. The Hoosiers come into this game with an 11-0 record, while the Boilermakers hold a 2-9 record. Indiana is ranked #2 in both the AP and Coaches Polls. The game is played on an outdoor field, adding an extra element to this Big Ten conference matchup.

Indiana vs. Purdue Betting Prediction

  • Money Line Prediction: Indiana Hoosiers -7500
    Indiana is ranked #2 and has an 11-0 record. They have won all their road games this season. Purdue has a 2-9 record and has struggled at home.
  • Over/Under Prediction: Over 54.5
    Indiana has a strong offense, ranking 2nd in points for this season. Their games often go over when the total is 50 or more.

Team Trends

  • Indiana Hoosiers hold an undefeated record of 11-0 this season.
  • Purdue Boilermakers have a home record of 2-4 this season.
  • Indiana Hoosiers are ranked #2 in both the AP and Coaches Polls.
  • Purdue Boilermakers have a conference record of 0-8 this season.
  • Indiana Hoosiers’ offense ranks 2nd in points scored this season with 476 points.

Indiana vs Purdue Preview

The Indiana Hoosiers are ready to continue their perfect season as they face the Purdue Boilermakers. Indiana holds an 11-0 record and sits at the top of the Big Ten standings. They are ranked #2 in both the AP and Coaches Polls. The Hoosiers have been strong on the road, winning all four away games this season.

Purdue enters the game with a 2-9 record and is at the bottom of the conference. The Boilermakers have struggled, losing their last nine games. Playing at home, they hope to turn things around at Ross-Ade Stadium. Both teams will battle under the lights on Friday night, with Indiana aiming to keep their win streak alive.

Purdue Boilermakers: Key Players and Team Performance

Purdue’s season has been challenging, with a record of 2-9. At home, they have won 2 out of 6 games. In the Big Ten Conference, they have not secured a victory yet, standing at 0-8.

Ryan Browne is the standout quarterback for Purdue. He has thrown for 1,915 yards and 9 touchdowns over 11 games. Malachi Singleton has also played a role, with 439 passing yards and 5 touchdowns in 10 games.

Devin Mockobee leads the rushing attack with 521 yards and 4 touchdowns, though he’s now out for the season. Antonio Harris and Malachi Thomas contribute with 274 and 237 rushing yards, respectively. Michael Jackson III is a top receiver with 57 catches and 504 yards over 11 games.

Indiana Hoosiers: Unbeaten and Dominant

Indiana Hoosiers hold a perfect season record of 11-0. They are ranked #2 in both the AP and Coaches polls. In their conference, they have an 8-0 record.

Quarterback Fernando Mendoza is a key player for Indiana. He has passed for 2,641 yards and 30 touchdowns. His performance is crucial to Indiana’s success.

Roman Hemby leads the rushing game with 714 yards and 5 touchdowns. On the receiving end, Omar Cooper Jr. has 764 yards and 10 touchdowns. Indiana’s offense ranks 2nd in points for this season with 476 points.

Final Betting Pick

Indiana is a strong pick on the money line. They have an 11-0 record and are ranked #2. They have won all their road games this season. Purdue has struggled with a 2-9 record and a poor home performance. Indiana’s recent games show their strength, like their 31-7 win against Wisconsin.

The over 54.5 prediction is also supported by Indiana’s offense. They rank 2nd in points for this season. Their games often go over when the total is 50 or more. Purdue’s defense has allowed many points, ranked 127th in points against. This makes the over a solid choice for this game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.