The James Madison Dukes will play against the Louisville Cardinals in Week 2 of the 2025 regular season. The game is set for Friday, September 5, 2025, at 7:00 PM. It will take place at L&N Federal Credit Union Stadium in Louisville, KY, and will be shown on ESPN2.

James Madison vs. Louisville Betting Prediction

• Money Line Prediction: James Madison Dukes +434. The Dukes have strong defense stats, allowing only 10 points in their last game. This makes them a good value pick despite being on the road.
• Over/Under Prediction: Under 57.5. Both teams have shown solid defense, with James Madison allowing only 10 points and Louisville 17 points in their last games.

Team Trends

• James Madison Dukes have a strong rushing game, ranking 10th with 313 rushing yards this season.
• Louisville Cardinals scored 51 points in their first game of the season, placing them 14th in points scored.
• The Dukes’ defense ranks 6th in points against, allowing only 10 points this season.
• Louisville Cardinals have a perfect home record of 1-0 this season.
• James Madison Dukes have not played any road games this season, with a road record of 0-0.

James Madison vs Louisville Preview

The James Madison Dukes are heading to L&N Federal Credit Union Stadium for their first road game of the 2025 season. They come in with a 1-0 record after winning at home. The Dukes are part of the Sun Belt Conference and are looking to extend their win streak. Last season, they ended on a high note by defeating Western Kentucky in the Boca Raton Bowl.

The Louisville Cardinals will host the Dukes with their own 1-0 record. The Cardinals are part of the Atlantic Coast Conference and have a strong home record. They recently secured a tight victory against Washington in the Tony the Tiger Sun Bowl. Both teams are currently unranked, making this game an opportunity to gain momentum early in the season.

Louisville Cardinals: Home Team Overview

The Louisville Cardinals play in the Atlantic Coast Conference. Their home games are at the L&N Federal Credit Union Stadium. This season, they hold a record of 1-0.

Miller Moss leads the quarterbacks with 223 passing yards and 1 touchdown. Isaac Brown stands out among running backs with 126 rushing yards and 2 touchdowns. Caullin Lacy is the top wide receiver with 62 receiving yards.

In offense, the team scored 51 points and gained 313 passing yards. On defense, they allowed 17 points and made 4 sacks. Nate Kurisky is questionable to play due to a hand injury.

James Madison Dukes: Away Team Insight

The James Madison Dukes play in the Sun Belt Conference. They had a strong start this season with a 1-0 record. Their last postseason game was the Boca Raton Bowl, where they won against Western Kentucky, 27-17.

Alonza Barnett III leads the Dukes’ quarterbacks with 130 passing yards and 1 touchdown. However, he is questionable for the next game due to a leg injury. In the running back department, George Pettaway has 99 rushing yards, and Wayne Knight adds 89 rushing yards with 1 touchdown.

Isaiah Alston is a key player in the wide receiver position with 31 receiving yards and 1 touchdown. The team’s defense has been strong, allowing only 10 points and making 3 interceptions. They also have a perfect 1-0 record against the spread this season.

Final Betting Pick

The James Madison Dukes are a solid pick for the money line at +434. Their defense is strong, allowing only 10 points in their last game. This makes them a good option even though they are playing away. The Dukes have a strong track record, winning their last postseason game against Western Kentucky.

The under 57.5 prediction is based on both teams’ defensive strengths. James Madison allowed only 10 points, while Louisville allowed 17 in their last games. With both teams showing solid defense, a lower scoring game is likely. This makes the under a smart choice for this matchup.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.