The Louisville Cardinals will play the Pittsburgh Panthers on Saturday, September 27, 2025. The game will take place at Acrisure Stadium in Pittsburgh, PA. Kickoff is set for 12:00 PM and will be broadcast on ESPN2. Louisville enters the game with a 3-0 record, while Pittsburgh holds a 2-1 record this season. Both teams are part of the Atlantic Coast Conference.

Louisville vs. Pittsburgh Betting Prediction

• Money Line Prediction: Louisville Cardinals (-191). Louisville has a strong start this season with a 3-0 record. They have not played on the road yet, but their overall performance is solid.
• Over/Under Prediction: Over 57.5. Both teams have shown the ability to score points, with Louisville scoring 119 and Pittsburgh 130 this season. This suggests a high-scoring game.

Team Trends

• The Louisville Cardinals have a perfect 3-0 record this season, but they have not played any road games yet.
• Pittsburgh Panthers are undefeated at home this season with a 2-0 record.
• Louisville’s defense ranks 8th in sacks with 10 this season.
• Pittsburgh’s offense has scored 130 points this season, ranking them 31st.
• The game will be played at Acrisure Stadium in Pittsburgh, PA, and will be shown on ESPN2.

Louisville vs Pittsburgh Preview

The Louisville Cardinals will visit the Pittsburgh Panthers in Week 5 of the 2025 season. Louisville is riding a 3-game win streak and has yet to play a road game this season. They are looking to continue their success in the Atlantic Coast Conference. The Cardinals have not played a conference game yet, making this matchup important for their standings.

Pittsburgh is coming off a loss, but they have been strong at home with a 2-0 record. They will aim to defend their turf at Acrisure Stadium. Both teams have not played a conference game this season, adding extra weight to this matchup. Fans can catch the action on ESPN2 at 12:00 PM.

Pittsburgh Panthers: Strong Start at Home

The Pittsburgh Panthers play in the Atlantic Coast Conference and call Acrisure Stadium their home. This season, they have a record of 2-1, with a perfect 2-0 at home. Despite a recent loss to West Virginia, the Panthers have shown they can perform on their turf.

Eli Holstein has been a standout quarterback for the Panthers this season. He has played in three games, throwing for 822 yards and nine touchdowns. With just three interceptions, Holstein’s performance has been key to the Panthers’ offensive success.

On the ground, Desmond Reid leads the running backs with 142 rushing yards and one touchdown. The receiving corps is led by Raphael Williams Jr., who has 285 receiving yards and three touchdowns. With a solid balance of passing and rushing, the Panthers’ offense ranks 52nd in passing yards this season.

Louisville Cardinals: Unbeaten and On the Road

The Louisville Cardinals are part of the Atlantic Coast Conference. They play their home games at L&N Federal Credit Union Stadium. This season, the Cardinals have an unbeaten record of 3-0, but they have not played any road games yet.

Miller Moss leads the Cardinals as their quarterback. Over three games, he has thrown for 690 yards with two touchdowns and two interceptions. Moss is a key player in the Cardinals’ offense, contributing to their 777 passing yards this season.

Isaac Brown stands out in the rushing attack, gaining 248 yards and scoring three touchdowns. In the receiving department, Caullin Lacy has 14 catches for 171 yards. The Cardinals’ balanced offense helps them rank 40th in points scored this season with 119 points.

Final Betting Pick

Louisville has shown a strong start with a 3-0 record. They have not played on the road yet, but their home performance suggests they are ready. Their recent win over Bowling Green, with a score of 40-17, highlights their ability to score and defend well.

Both teams have high-scoring offenses. Louisville has scored 119 points, while Pittsburgh has scored 130. This suggests the game will likely go over the 57.5 total. With both teams ranking in the top 50 for points scored, expect a high-scoring game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.