Ohio State Buckeyes vs Indiana NCAAF Betting Prediction
PublishedDecember 2, 2025,            Posted By: Maria Uebelhor
Last updated:December 2, 2025 ,

NCAAF Ohio State Buckeyes vs Indiana Prediction 12/6

On Saturday, December 6, 2025, the Ohio State Buckeyes will play against the Indiana Hoosiers in the Big Ten Championship. The game will take place at Lucas Oil Stadium in Indianapolis, IN, with kickoff at 8:00 PM. Fans can watch the game on FOX as these two undefeated teams compete.

Ohio State vs. Indiana Betting Prediction

  • Money Line Prediction: Ohio State Buckeyes -202. Ohio State is ranked #1 and has a perfect 12-0 record. They have a strong track record in away games, winning 23 of their last 26.
  • Over/Under Prediction: Over 48.5. Indiana’s games have often gone over, with a 5-1 record in home games this season. Their offense ranks 2nd in points for this season.

Team Trends

  • Ohio State Buckeyes are ranked #1 in both the AP and Coaches Polls.
  • Indiana Hoosiers are ranked #2 in both the AP and Coaches Polls.
  • Ohio State Buckeyes have an unbeaten road record of 5-0 this season.
  • Indiana Hoosiers have an unbeaten home record of 7-0 this season.
  • The game will be played at Lucas Oil Stadium in Indianapolis, IN, which is a dome stadium.

Ohio State vs Indiana Preview

The Ohio State Buckeyes and Indiana Hoosiers are set for a big game in the Big Ten Championship. Both teams have perfect 12-0 records this season. Ohio State holds the top spot in the AP and Coaches Polls, while Indiana sits at number two. Each team has a strong conference record of 9-0. This game will take place at Lucas Oil Stadium in Indianapolis, a neutral site for both teams.

Ohio State comes into this game with a 12-game winning streak. They played their last postseason game against Notre Dame, winning 34-23. Indiana also has a 12-game winning streak but lost their last postseason game to Notre Dame, 27-17. The Buckeyes have proven themselves on the road with a 5-0 record, while the Hoosiers have matched that with their own 5-0 road record. Fans can expect a great game as these two undefeated teams meet on Saturday night.

Indiana Hoosiers: A Closer Look

The Indiana Hoosiers are ranked #2 in both the AP and Coaches Polls. They play in the Big Ten Conference and call Memorial Stadium in Bloomington, IN, their home. This season, they have a perfect 12-0 record, with an impressive 7-0 home record.

Fernando Mendoza leads the Hoosiers as quarterback with 2,758 passing yards and 32 touchdowns in 12 games. Roman Hemby is the top running back, rushing for 866 yards and six touchdowns. Wide receiver Omar Cooper Jr. has 828 receiving yards and 11 touchdowns.

The Hoosiers’ offense ranks 2nd in points scored with 532 and 9th in rushing yards with 2,830. Their defense is strong, with 34 sacks and 17 interceptions this season. Despite injuries to key players like E.J. Williams Jr. and Bryson Bonds, the Hoosiers continue to perform well on the field.

Ohio State Buckeyes: Dominant Leaders

Ohio State Buckeyes hold the top rank in both the AP and Coaches Polls. They share the Big Ten Conference with Indiana. This season, Ohio State boasts a perfect 12-0 record, with a 5-0 record on the road. Their last notable win was against Michigan, finishing 27-9.

The Buckeyes’ offense is led by quarterback Julian Sayin, who has thrown for 3,065 yards and 30 touchdowns. Running back Bo Jackson leads the team with 952 rushing yards and five touchdowns. Wide receiver Jeremiah Smith has 942 receiving yards and 11 touchdowns this season.

Ohio State’s team offense ranks 13th in points with 444 and 25th in passing yards with 3,204. Their defense has shown strength with 30 sacks and seven interceptions. Despite injuries to key players like Mason Maggs and Quincy Porter, Ohio State remains a tough team to face.

Final Betting Pick

Ohio State has a strong away record, winning 23 of their last 26 games on the road. This makes them a solid pick for the money line at -202. They have shown consistent performance in away games, which boosts confidence in their ability to win against Indiana.

The over/under prediction of over 48.5 is backed by Indiana’s high-scoring home games. Indiana’s offense ranks 2nd in points this season, often pushing games over the total. With both teams having strong offenses, the likelihood of a high-scoring game is increased.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.