The South Carolina Gamecocks will take on the Missouri Tigers in Week 4 of the 2025 regular season. This game is set for Saturday, September 20, 2025, at 7:00 PM ET. The game will be played at Faurot Field at Memorial Stadium in Columbia, MO, and will be broadcast on ESPN.

South Carolina vs. Missouri Betting Prediction

• Money Line Prediction: Missouri Tigers -527. Missouri has a strong home record this season, winning all three home games. South Carolina has struggled in conference play with a 0-1 record.
• Over/Under Prediction: Over 46.5. Missouri’s games have gone over in all three games this season, and their offense is ranked 6th in points scored.

Team Trends

• South Carolina Gamecocks are ranked #24 in the Coaches Poll.
• Missouri Tigers hold a perfect 3-0 home record this season.
• Missouri Tigers are ranked #23 in the AP Poll and #22 in the Coaches Poll.
• South Carolina Gamecocks have a 1-0 road record this season.
• Missouri Tigers have scored 155 points this season, ranking 6th in the nation.

South Carolina vs Missouri Preview

The South Carolina Gamecocks are heading into Week 4 with a 2-1 record. They are ranked #24 in the Coaches Poll. Their only loss this season came in conference play. They are looking to bounce back from a one-game losing streak. The Gamecocks are on the road this week, where they have already secured a win this season.

The Missouri Tigers have started the season strong with a 3-0 record. They hold the #23 spot in the AP Poll and are ranked #22 in the Coaches Poll. The Tigers have been unbeatable at home, with three wins at Faurot Field. They are on a three-game winning streak and will aim to keep it going against South Carolina.

Missouri Tigers: Strong Start and Key Players

The Missouri Tigers are ranked #23 in the AP Poll and #22 in the Coaches Poll. They play in the Southeastern Conference and call Faurot Field at Memorial Stadium their home. This season, they hold a 3-0 record, with all wins coming at home.

Beau Pribula is the standout quarterback with 791 passing yards and 7 touchdowns in three games. Ahmad Hardy shines as a top running back, leading with 462 rushing yards and 5 touchdowns. Kevin Coleman Jr. leads the wide receivers with 24 receptions and 258 receiving yards.

Missouri’s offense ranks 6th in points scored with 155 points. They have gained 909 rushing yards, placing them 3rd overall. On the defensive side, they have allowed 47 points, ranking 32nd, and have made 7 sacks.

South Carolina Gamecocks: Key Players and Season Overview

The South Carolina Gamecocks are ranked #24 in the Coaches Poll. They play in the Southeastern Conference and call Williams-Brice Stadium their home. This season, they have a record of 2-1, with a road record of 1-0.

LaNorris Sellers is a top quarterback, with 431 passing yards and 2 touchdowns in three games. Rahsul Faison leads the rushing attack with 135 rushing yards and 1 touchdown. Nyck Harbor stands out among wide receivers, recording 7 receptions and 165 receiving yards.

South Carolina’s offense has scored 69 points, ranking them 58th in points scored. They have accumulated 591 passing yards and 337 rushing yards. Defensively, they have allowed 52 points and have recorded 8 sacks, ranking 6th overall.

Final Betting Pick

Missouri Tigers are a solid pick for the money line at -527. They have a perfect home record, winning all three games at Faurot Field. Their offense is ranked 6th in points scored, which gives them a strong edge.

The over 46.5 is a good choice for this game. Missouri’s games have gone over in all three games this season. Their offense has been scoring a lot, which should help push the total over the line again.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.