On Saturday, September 27, 2025, the USC Trojans will visit the Illinois Fighting Illini at Memorial Stadium in Champaign, IL. This Week 5 game of the 2025 regular season will kick off at 12:00 PM and will be broadcast on FOX. USC comes into the game with a 4-0 record, while Illinois holds a 3-1 record.

USC vs. Illinois Betting Prediction

• Money Line Prediction: USC Trojans at -247. USC is undefeated this season with a 4-0 record. They have shown strong performance both at home and on the road. Illinois struggled in their last game, losing 63-10 to Indiana.
• Over/Under Prediction: Over 59.0. USC has scored 210 points this season, ranking 3rd in points for. Illinois has allowed 85 points this season, which could lead to a high-scoring game.

Team Trends

• USC Trojans are ranked #21 in the AP Poll and #22 in the Coaches Poll.
• Illinois Fighting Illini hold a perfect 2-0 home record this season.
• USC Trojans have a strong road record of 1-0 this season.
• The last time Illinois played at home, they won 38-0 against Western Michigan.
• USC Trojans have scored 210 points this season, ranking 3rd in the nation.

USC vs Illinois Preview

The USC Trojans are set to take on the Illinois Fighting Illini in an exciting Week 5 game. USC holds a perfect 4-0 record, with their recent win streak boosting their confidence. Ranked #21 in the AP Poll, the Trojans have shown strength in both home and away games. Their road record stands at 1-0, and they have already secured two conference wins this season.

Illinois enters the game with a 3-1 record, eager to bounce back from a recent loss. The Fighting Illini are ranked #23 in both the AP and Coaches Polls. They have been strong at home, winning both games played at Memorial Stadium this season. This game is crucial for Illinois as they seek their first conference win of the year.

Illinois Fighting Illini Overview

The Illinois Fighting Illini hold the #23 rank in both the AP and Coaches Poll. They are part of the Big Ten Conference and play their home games at Memorial Stadium in Champaign, IL. This season, they have a 3-1 record with a 2-0 home record and a 1-1 road record.

Quarterback Luke Altmyer leads the team with 855 passing yards, 9 touchdowns, and zero interceptions over four games. On the ground, Kaden Feagin has rushed for 240 yards and scored 3 touchdowns. The top wide receiver, Hank Beatty, has 302 receiving yards and 1 touchdown so far.

Illinois scored 145 points this season, ranking 21st, with 882 passing yards and 502 rushing yards. Their defense has allowed 85 points and recorded 11 sacks and 5 fumbles recovered. In their last postseason game, Illinois won against South Carolina in the Cheez-It Citrus Bowl, 21-17.

USC Trojans: Road Warriors

The USC Trojans are having a strong season with a perfect 4-0 record. They are ranked #21 in the AP Poll and #22 in the Coaches Poll. The Trojans play in the Big Ten Conference and their home field is the Los Angeles Memorial Coliseum.

Quarterback Jayden Maiava is leading the Trojans with 1,223 passing yards and 9 touchdowns in four games. Waymond Jordan is the top running back, rushing for 443 yards and scoring 3 touchdowns. Wide receiver Makai Lemon has 438 receiving yards and 3 touchdowns.

USC has scored 210 points this season, which ranks them 3rd in the nation. They have 1,326 passing yards and 1,010 rushing yards. On defense, they have allowed 81 points and recorded 16 sacks.

Final Betting Pick

USC is a strong pick for the money line at -247. They have an undefeated record of 4-0, showing they can win both at home and on the road. Their recent win over Michigan State, 45-31, highlights their ability to perform under pressure. Illinois, on the other hand, struggled in their last game with a big loss to Indiana, 63-10. This difference in recent performances makes USC a reliable choice.

The over/under prediction of over 59.0 is also reasonable. USC has scored 210 points this season, ranking them third in points scored. Their offense is strong, with high passing and rushing yards. Illinois has allowed 85 points this season, which could lead to a high-scoring game. With both teams having the potential to score, the over looks promising.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.