The USC Trojans will meet the Purdue Boilermakers in Week 3 of the 2025 regular season. This game will take place on Saturday, September 13, 2025, at Ross-Ade Stadium in West Lafayette, IN. Kickoff is set for 3:30 PM and will be broadcast on CBS.

USC vs. Purdue Betting Prediction

• Money Line Prediction: Purdue Boilermakers +922. Purdue is strong at home with a 2-0 record, making them a good value pick against USC.
• Over/Under Prediction: Over 58.5. USC’s games have been high-scoring, with both previous games going over the total.

Team Trends

• USC Trojans have a perfect 2-0 record this season, but both wins were at home.
• Purdue Boilermakers also have a 2-0 record this season, with both wins coming at Ross-Ade Stadium.
• USC Trojans lead the nation in points scored with 132 in the 2025 season.
• Purdue Boilermakers have not allowed any interceptions this season, ranking first in that category.
• The game will be played at Ross-Ade Stadium in West Lafayette, IN, and will be broadcast on CBS.

USC vs Purdue Preview

The USC Trojans are set to take on the Purdue Boilermakers in Week 3 of the 2025 season. Both teams have started strong, each holding a 2-0 record. The Trojans have played both their games at home, while Purdue has also enjoyed success at Ross-Ade Stadium, where this game will take place.

USC and Purdue are both part of the Big Ten conference. The Trojans are currently on a two-game winning streak and ranked 9th in the conference. Purdue also has a two-game streak and sits 3rd in the conference rankings. This game will be a test for both teams as they aim to maintain their unbeaten records.

Purdue Boilermakers: Key Players and Team Performance

The Purdue Boilermakers play in the Big Ten Conference. Their home games are held at Ross-Ade Stadium. This season, Purdue has a 2-0 record, all from home games.

Quarterback Ryan Browne has played in two games, passing for 481 yards, ranking first in the team for passing yards. He also has four passing touchdowns and one interception. Running back Devin Mockobee stands out with 185 rushing yards and three rushing touchdowns in two games.

Wide receiver Arhmad Branch has contributed significantly with 132 receiving yards and two touchdowns. The Boilermakers’ team offense has scored 65 points this season, ranking 29th. Their defense ranks 9th in points against, allowing only 17 points this season.

USC Trojans: Rising Stars and Impressive Stats

USC Trojans are part of the Big Ten Conference and play at the Los Angeles Memorial Coliseum. They have a strong start this season with a 2-0 record. Both wins came from home games.

Quarterback Jayden Maiava has been impressive with 707 passing yards in two games. He has thrown six touchdowns without any interceptions. Maiava ranks first in the team for passing yards and touchdowns.

Running back Waymond Jordan leads with 209 rushing yards and two touchdowns. Wide receiver Makai Lemon has 248 receiving yards and two touchdowns. The Trojans’ offense is ranked first in points with 132 scored this season.

Final Betting Pick

Purdue is a strong pick for the money line at +922. They have a perfect home record of 2-0 this season. Playing at Ross-Ade Stadium gives them an edge, as they have shown solid performance on their turf. Their recent win against Southern Illinois, 34-17, shows their ability to handle pressure at home.

The over 58.5 is a good choice because USC’s games have been high-scoring. They scored 59 and 73 points in their first two games. Purdue’s defense will need to step up, but the potential for a high total is there. With both teams having strong offenses, this game could easily go over the total.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.