Vanderbilt Commodores vs South Carolina NCAAF Betting Prediction
PublishedSeptember 9, 2025,            Posted By: Maria Uebelhor
Last updated:September 9, 2025 ,

NCAAF Vanderbilt vs South Carolina Prediction 9/13

The Vanderbilt Commodores will take on the South Carolina Gamecocks in Week 3 of the 2025 regular season. The game is set for Saturday, September 13, 2025, at 7:45 PM at Williams-Brice Stadium in Columbia, SC. Fans can catch the action on SECN as both teams look to continue their strong starts to the season.

Vanderbilt vs. South Carolina Betting Prediction

  • Money Line Prediction: Vanderbilt Commodores +171. Vanderbilt has a strong start this season with a 2-0 record. Their recent win against Virginia Tech shows they can perform well on the road.
  • Over/Under Prediction: Over 48.5 (-109). Both teams have shown they can score, with Vanderbilt putting up 89 points and South Carolina scoring 62 points in their first two games.

Team Trends

  • Vanderbilt Commodores have a perfect 2-0 record this season, with one win on the road.
  • South Carolina Gamecocks are ranked #11 in the AP Poll and #10 in the Coaches Poll.
  • Vanderbilt defeated Virginia Tech Hokies 44-20 in an away game during Week 2.
  • South Carolina won their last home game against South Carolina State Bulldogs 38-10.
  • Vanderbilt’s defense ranks 2nd in interceptions with one interception this season.

Vanderbilt vs South Carolina Preview

The Vanderbilt Commodores are ready for their Week 3 game against the South Carolina Gamecocks. Both teams have started the season strong with a 2-0 record. Vanderbilt has shown strength on the road, winning their only away game so far. They are unranked but hold a two-game win streak. The Commodores are looking to make a mark in the Southeastern Conference.

South Carolina comes into this game ranked 11th in the AP Poll and 10th in the Coaches Poll. They also have a 2-0 record and are on a two-game win streak. The Gamecocks will play at home in Williams-Brice Stadium, where they have already secured a win this season. Both teams aim to keep their momentum going in this early-season conference showdown.

Gamecocks on a Winning Streak

The South Carolina Gamecocks have started the season strong with a 2-0 record. They are ranked #11 in the AP poll and #10 in the Coaches Poll. Both of their wins came on the road and at their home, Williams-Brice Stadium.

Quarterback LaNorris Sellers is a key player for the Gamecocks. He has thrown for 337 yards in two games, ranking 1st on the team. Sellers has also contributed 2 passing touchdowns, adding to his strong performance.

On the ground, Oscar Adaway III leads the rushing attack. He has gained 80 yards and scored 1 rushing touchdown in two games. In the receiving department, Nyck Harbor has caught 3 passes for 99 yards and 1 touchdown, making him a top receiver for the team.

Vanderbilt Commodores on the Road

The Vanderbilt Commodores have kicked off the season with a 2-0 record. They are part of the Southeastern Conference. In their last postseason game, they played in the Birmingham Bowl, beating Georgia Tech 35-27.

Diego Pavia stands out as the top quarterback for the Commodores. He has thrown for 468 yards in two games. Pavia has also recorded 5 passing touchdowns, making him a key player in their offense.

On the ground, Sedrick Alexander leads the team with 156 rushing yards and 2 touchdowns. Tre Richardson is a top receiver with 128 receiving yards and 1 touchdown. The Commodores’ offense has put up 89 points this season, ranking them 13th in points scored.

Final Betting Pick

Vanderbilt’s money line at +171 is a solid pick. They have started the season strong with a 2-0 record. Their recent win against Virginia Tech, where they scored 44 points on the road, shows their ability to perform well away from home. This makes them a good choice for an upset against South Carolina.

The over 48.5 points is also a good choice. Vanderbilt has scored 89 points in their first two games, while South Carolina has scored 62. Both teams have shown they can put up points, making the over a reasonable bet. With both teams having strong offenses, a high-scoring game is likely.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.