The Virginia Cavaliers will travel to face the Louisville Cardinals on Saturday, October 4, 2025. The game is set to kick off at 3:30 PM at L&N Federal Credit Union Stadium in Louisville, KY. Fans can catch the action on ESPN2. Both teams are part of the Atlantic Coast Conference, with Virginia holding a 4-1 record and Louisville standing at 4-0 this season.

Virginia vs. Louisville Betting Prediction

• Money Line Prediction: Louisville -283. Louisville has a strong home record of 3-0 this season. They have also been successful as favorites, winning 22 of their last 26 games in that role.
• Over/Under Prediction: Over 62.5. Both teams have shown high-scoring games recently. Virginia’s last six games have all gone over the total, and Louisville’s games have also seen high scores.

Team Trends

• Virginia Cavaliers are ranked #24 in the AP rankings.
• Virginia has a road record of 0-1 this season.
• Louisville Cardinals have a perfect home record of 3-0 this season.
• Virginia Cavaliers have scored 228 points this season, ranking 6th in points for.
• Louisville Cardinals have allowed 75 points this season, ranking 45th in points against.

Virginia vs Louisville Preview

The Virginia Cavaliers are heading to Louisville to take on the Cardinals in an Atlantic Coast Conference game. Virginia has a 4-1 record and is ranked 24th in the AP poll. They have been strong at home with a perfect 4-0 record, but they have struggled on the road, losing their only away game so far.

Louisville stands unbeaten at 4-0, with a strong 3-0 record at home. They are currently on a four-game win streak, sitting at the top of the conference rankings. This game will test both teams as Virginia aims to improve their road performance, while Louisville looks to maintain their winning streak. Fans can watch the game on ESPN2 at 3:30 PM.

Louisville Cardinals: Home Team Overview

The Louisville Cardinals are off to a strong start this season with a perfect 4-0 record. They have been dominant at home, winning all three games played at L&N Federal Credit Union Stadium. Their conference record stands at 1-0, showcasing their competitive edge in the Atlantic Coast Conference.

Miller Moss leads the Cardinals at the quarterback position with 1,029 passing yards in four games. He has thrown five touchdowns and three interceptions, ranking first on the team in passing touchdowns. Isaac Brown is another key player, contributing 268 rushing yards and three touchdowns, also ranking first on the team.

On the receiving end, Chris Bell stands out with 23 receptions totaling 332 yards and two touchdowns. The team has scored 153 points this season, ranking 31st in the league. Defensively, Louisville has allowed 75 points and recorded 12 sacks, making them a force to reckon with on both sides of the ball.

Virginia Cavaliers: Road Team Insights

The Virginia Cavaliers hold a 4-1 record this season. They won all four home games but have not yet secured a victory on the road. In their conference, they have a strong 2-1 record, placing them in good standing.

Chandler Morris leads the team as quarterback with 1,279 passing yards over five games. He has thrown ten touchdowns and four interceptions. This places him as the top quarterback for the Cavaliers in multiple categories.

J’Mari Taylor is the standout running back with 397 rushing yards and seven touchdowns. Trell Harris is a key receiver, boasting 366 receiving yards and three touchdowns. Together, these players drive the Cavaliers’ offensive efforts.

Final Betting Pick

Louisville is a strong pick for the money line at -283. They have an impressive home record this season, winning all three games. Louisville has also been successful as favorites, winning 22 of their last 26 games in that role. This shows they perform well when expected to win, making them a reliable choice.

The over 62.5 is a solid pick for this game. Both teams have been involved in high-scoring games recently. Virginia’s last six games have all gone over the total. Louisville’s games have also seen high scores, indicating that both teams have potent offenses. This trend suggests a high-scoring game is likely.

From kickoff on Saturdays to the final whistle on Sundays, Action 24/7 is giving you more reasons to cheer. Get a 10% College Football & NFL boost on spreads and totals every game day. Bet your favorites, back your instincts, and boost your winnings with Action 24/7.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.