Arizona Cardinals vs Los Angeles Rams NFL Betting Prediction
PublishedDecember 31, 2025,            Posted By: Maria Uebelhor
Last updated:December 31, 2025 ,

NFL Arizona Cardinals vs Los Angeles Rams Prediction 1/4

The Arizona Cardinals will play against the Los Angeles Rams on Sunday, January 4, 2026. The game will take place at SoFi Stadium in Inglewood, CA, and is scheduled for 4:25 PM. Fans can catch the game on FOX, and while the weather forecast mentions light rain, the dome stadium ensures a dry game day experience.

Cardinals vs. Rams Betting Prediction

  • Money Line Prediction: Los Angeles Rams (-334). The Rams have a strong home record of 6-1, making them a solid choice against the struggling Cardinals, who are 2-6 on the road.
  • Over/Under Prediction: Over 46.5 (-110). Both teams have shown the ability to score, and their recent game ended with a total of 62 points, suggesting a high-scoring game is likely.

Team Trends

  • Arizona Cardinals have a 3-13 record this season, with a 2-6 record on the road.
  • Los Angeles Rams have a strong home record of 6-1 this season.
  • Arizona Cardinals lost their last game against the Cincinnati Bengals with a score of 37-14.
  • Los Angeles Rams won their last home game against the Detroit Lions with a score of 41-34.
  • In their last meeting, the Rams defeated the Cardinals 45-17 at State Farm Stadium.

Cardinals vs Rams Preview

The Arizona Cardinals head into Week 18 with a challenging task against the Los Angeles Rams. The Cardinals have struggled this season, holding a 3-13 record and sitting at the bottom of the NFC West. Jacoby Brissett, the Cardinals’ quarterback, is projected to pass for 231.3 yards and 1.5 touchdowns. He will look to connect with key targets like Michael Wilson and Trey McBride.

The Rams, with an 11-5 record, are third in the NFC West. They aim to end their two-game losing streak. Matthew Stafford leads the Rams’ offense and is expected to pass for 266.9 yards and 2.1 touchdowns. The Rams’ running game, led by Kyren Williams, adds depth with projections of 64.6 rushing yards and 0.5 touchdowns. The Rams hope to capitalize on their home advantage at SoFi Stadium.

Rams Ready to Shine at SoFi Stadium

Matthew Stafford leads the Los Angeles Rams with high expectations. He is projected to throw for 266.9 yards and score 2.1 touchdowns in the upcoming game. His past performance in the season includes 4,448 passing yards, ranking first in the league.

Kyren Williams is the top running back for the Rams. He is expected to rush for 64.6 yards and score 0.5 touchdowns. His season stats include 1,192 rushing yards, placing him first on the team.

Sean McVay, the head coach, has guided the Rams to an 11-5-0 record this season. The team’s offense ranks 10th in passing yards with 3,868. Their defense has recorded 38 sacks, ranking 11th in the league.

Cardinals Gear Up for Showdown

Jacoby Brissett leads the Arizona Cardinals as their starting quarterback. He is projected to pass for 231.3 yards and score 1.5 touchdowns. This season, Brissett has thrown for 3,123 yards and 21 touchdowns, ranking first on his team.

Michael Carter is the primary running back for the Cardinals. He is expected to rush for 40.3 yards and catch 1.7 passes in the upcoming game. Carter has amassed 315 rushing yards and 30 receptions this season.

Head coach Jonathan Gannon aims to improve the Cardinals’ current 3-13 record. The team’s offense scored 400 points last season, placing them 12th in the league. On defense, the Cardinals recorded 41 sacks, ranking 8th overall.

Final Betting Pick

The Rams are a strong pick for the money line at -334. They have a great home record of 6-1 this season. The Cardinals have struggled on the road with a 2-6 record, making them less likely to win.

For the over/under, taking the over at 46.5 is a good choice. The Rams and Cardinals scored a total of 62 points in their last game. Both teams have shown they can score, so a high-scoring game is expected.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.