The Denver Broncos will play the Indianapolis Colts on Sunday, September 14, 2025. This Week 2 game will take place at Lucas Oil Stadium in Indianapolis. The game is set to start at 4:05 PM and will be broadcast on CBS.

Broncos vs. Colts Betting Prediction

• Money Line Prediction: Colts +107. The Colts have a strong home record, winning their last game against the Dolphins with a 33-8 score. Playing at home again gives them an edge.
• Over/Under Prediction: Over 42.5 (-110). Both teams showed offensive strength in their last games, with the Colts scoring 33 points and the Broncos scoring 20 points. This trend suggests a higher scoring game.

Team Trends

• The Denver Broncos are led by head coach Sean Payton and have a current season record of 1-0-0.
• The Broncos won their first game of the season against the Tennessee Titans with a score of 20-12.
• The Indianapolis Colts, with head coach Shane Steichen, also hold a season record of 1-0-0.
• The Colts won their first home game of the season against the Miami Dolphins, finishing 33-8.
• Lucas Oil Stadium, the Colts’ home field, has a retractable roof which may negate any weather impact.

Broncos vs Colts Preview

The Denver Broncos and Indianapolis Colts are both coming off wins in Week 1. The Broncos are second in the AFC West, while the Colts lead the AFC South. Both teams will aim to keep their winning streaks alive in this Week 2 game at Lucas Oil Stadium.

Bo Nix, the Broncos’ quarterback, is projected to throw for 228.6 yards and 1.6 touchdowns. On the other side, Colts quarterback Daniel Jones is expected to pass for 225.2 yards and 1.4 touchdowns. Jonathan Taylor, the Colts’ running back, is projected to rush for 81.1 yards, while J.K. Dobbins of the Broncos is expected to gain 61.2 rushing yards. Both teams will rely on their key players to make an impact in this matchup.

Colts Ready for Action

The Indianapolis Colts are having a good start with a 1-0 record for the season. Head Coach Shane Steichen is leading the team in the AFC South. The Colts play their home games at Lucas Oil Stadium, where they are unbeaten this season.

Quarterback Daniel Jones is set to lead the offense, with projections of 225.2 passing yards and 1.4 touchdowns. Running back Jonathan Taylor is expected to contribute with 81.1 rushing yards and 0.7 touchdowns. Wide receiver Michael Pittman Jr. aims to make an impact with 56.5 receiving yards and 0.3 touchdowns.

The Colts’ defense will need to perform well, especially with several key players out due to injury. The team is missing players like D.J. Montgomery and Salvon Ahmed. The defense will rely on other players to step up and fill the gaps left by these injuries.

Broncos Set for Road Test

The Denver Broncos are coming off a strong start with a 1-0 record. They are led by Head Coach Sean Payton in the AFC West. Bo Nix is the starting quarterback and is projected to throw for 228.6 yards and 1.6 touchdowns in this game.

Running back J.K. Dobbins is expected to gain 61.2 rushing yards and score 0.5 touchdowns. Courtland Sutton is a key target, with 65.5 receiving yards and 0.4 touchdowns projected. The Broncos play their home games at Empower Field at Mile High.

The team had a solid performance last season, ranking 10th in scoring offense. Defensively, they ranked 3rd in opponent scoring and 1st in sacks. Key players like Michael Burton and Malcolm Roach are out, which could impact the team’s performance.

Final Betting Pick

The Colts are a good pick for the money line at +107. Their strong home performance against the Dolphins, where they won 33-8, shows their ability to play well at Lucas Oil Stadium. Daniel Jones leads the offense with 225.2 passing yards projected for this game, adding to their home advantage.

The over 42.5 is a solid choice because both teams have shown they can score. The Colts put up 33 points in their last game, while the Broncos scored 20 against the Titans. With both teams having strong offensive players, like Jonathan Taylor for the Colts and J.K. Dobbins for the Broncos, a high-scoring game is likely.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.