The Denver Broncos will play against the Los Angeles Chargers on Sunday, September 21, 2025. The game will take place at SoFi Stadium in Inglewood, CA. Tune in at 4:05 PM on CBS to catch all the action.

Broncos vs. Chargers Betting Prediction

• Money Line Prediction: Chargers -155. The Chargers have a strong start this season with a 2-0 record, including a win at home. They have shown solid performance both offensively and defensively.
• Over/Under Prediction: Under 45.5. Both teams have strong defenses, with the Chargers allowing only 301 points last season and the Broncos ranking 3rd in opponent score. This could lead to a lower-scoring game.

Team Trends

• The Denver Broncos have a road record of 0-1 this season.
• The Los Angeles Chargers have a perfect 2-0 record this season.
• Justin Herbert, the Chargers’ quarterback, threw for 318 yards and 3 touchdowns in their Week 1 home game.
• The Broncos’ quarterback, Bo Nix, completed 22 passes for 206 yards and 3 touchdowns in their recent game against the Colts.
• The Chargers’ defense intercepted 3 passes in their Week 2 game against the Raiders.

Broncos vs Chargers Preview

The Denver Broncos head to SoFi Stadium to play the Los Angeles Chargers in Week 3 of the 2025 NFL season. The Broncos have a 1-1 record and aim to bounce back after a loss. The Chargers are off to a strong start with a 2-0 record, leading the AFC West division.

Quarterback Bo Nix leads the Broncos with a projected 215.8 passing yards and 1.6 touchdowns. Running back J.K. Dobbins is expected to add 69.4 rushing yards. For the Chargers, Justin Herbert is projected to throw for 245.4 yards and 1.5 touchdowns. Omarion Hampton could contribute with 60 rushing yards. Both teams will look to capitalize on their strengths in this game.

Chargers Look to Maintain Strong Start

The Los Angeles Chargers are off to a strong start this season with a 2-0 record. Justin Herbert is leading the team as the starting quarterback, projected to throw for 245.4 yards and 1.5 touchdowns in the upcoming game. Under head coach Jim Harbaugh, the Chargers have been solid both at home and on the road.

Omarion Hampton is making an impact in the running game, with a projection of 60 rushing yards and 0.5 touchdowns. The wide receiver group is also strong, with Ladd McConkey expected to add 71.9 receiving yards and 0.4 touchdowns. The Chargers’ offense looks to continue its balanced attack in their next outing.

The Chargers’ defense is coming off a season where they ranked first in opponent score, allowing only 301 points. They will aim to keep up the pressure with key defensive players stepping up. Despite some injuries, the team remains confident in maintaining their solid defensive performance.

Broncos Ready to Challenge Chargers

The Denver Broncos are set to take on the Chargers. Bo Nix leads the team at quarterback with 215.8 projected passing yards and 1.6 touchdowns. Head coach Sean Payton will guide the team as they aim to improve their 1-1 record.

J.K. Dobbins plays a key role in the Broncos’ run game. He is expected to rush for 69.4 yards and potentially score a touchdown. On the receiving end, Courtland Sutton could add 59.4 yards to the team’s offense.

Last season, Denver ranked third in opponent score, allowing 311 points. They also led the league with 63 sacks. Despite several injuries, the Broncos’ defense seeks to maintain their strong presence on the field.

Final Betting Pick

The Chargers are favored on the money line at -155. They have started the season strong with a 2-0 record. Playing at home, they have already secured a win, which adds to their confidence. Justin Herbert is expected to lead the offense with 245.4 passing yards and 1.5 touchdowns. This gives the Chargers an edge, especially with their solid defense that allowed only 301 points last season.

The over/under is set at 45.5, and the prediction is for the total to go under. Both teams have strong defenses. The Broncos were third in opponent score last season, while the Chargers were first. With both defenses performing well, a lower-scoring game is likely. The Broncos’ recent game against the Colts ended with a total of 57 points, but their game against the Titans had only 32 points, showing their defense can keep scores low.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.