Jacksonville Jaguars vs San Francisco 49ers NFL Betting Prediction
PublishedSeptember 24, 2025,            Posted By: Maria Uebelhor
Last updated:September 24, 2025 ,

NFL Jaguars vs San Francisco 49ers Prediction 9/28

The Jacksonville Jaguars will visit the San Francisco 49ers at Levi’s Stadium on Sunday, September 28, 2025. This game is set for 4:05 PM and will be broadcast on FOX. The Jaguars come into this game with a 2-1 record, while the 49ers are unbeaten at 3-0. Both teams will aim to continue their strong starts to the season.

Jaguars vs. 49ers Betting Prediction

  • Money Line Prediction: San Francisco 49ers at -174. The 49ers have a strong home record, winning their only home game this season. They also have a perfect 3-0 record overall, making them a reliable choice at home.
  • Over/Under Prediction: Under 47.0. Both teams have shown solid defensive performances in recent games, with the 49ers allowing only 15 points in their last home game. This suggests a lower-scoring game.

Team Trends

  • The San Francisco 49ers are unbeaten this season with a 3-0 record.
  • Jacksonville Jaguars have a 0-1 record in away games this season.
  • The 49ers won their last home game against the Arizona Cardinals 16-15.
  • Trevor Lawrence threw for 271 yards and 3 touchdowns in the Jaguars’ recent game against the Cincinnati Bengals.
  • Christian McCaffrey had 52 rushing yards and 10 receptions in the 49ers’ last game against the Cardinals.

Jaguars vs 49ers Preview

The Jacksonville Jaguars head to Levi’s Stadium to take on the San Francisco 49ers. The Jaguars have a 2-1 record and sit second in the AFC South. Quarterback Trevor Lawrence is expected to lead the offense with 225.1 passing yards. Running back Travis Etienne Jr. is projected to add 59.5 rushing yards. The Jaguars will look to challenge the 49ers’ strong defense.

The 49ers are 3-0 and lead the NFC West. Quarterback Brock Purdy is expected to throw for 269.7 yards. Running back Christian McCaffrey is projected to contribute 75.5 rushing yards. The 49ers aim to maintain their unbeaten streak at home. Both teams will rely on their key players to make a difference in this game.

San Francisco 49ers: A Strong Start

The San Francisco 49ers are off to a great start this season with a record of 3-0-0. They have been strong both at home and on the road. Head coach Kyle Shanahan has led the team to success in the NFC West division.

Brock Purdy is expected to perform well, with projections of 269.7 passing yards and 1.7 touchdowns for this game. Christian McCaffrey is another key player, projected to rush for 75.5 yards and make 5.3 receptions. Ricky Pearsall is set to shine among the wide receivers, with an expected 65.8 receiving yards.

The team’s offense ranked 4th in passing yards last season, accumulating 4,234 yards. The defense has been effective, ranking 9th in opponent passing interceptions. Despite some injuries, including George Kittle and Nick Bosa, the 49ers are maintaining their strong form.

Jacksonville Jaguars: Aiming for Road Success

The Jacksonville Jaguars hold a 2-1-0 record this season. Head coach Liam Coen has guided the team to wins at home, but they seek their first road victory. They are part of the AFC South division.

Trevor Lawrence is the starting quarterback for the Jaguars. He is projected to throw for 225.1 yards and 1.4 touchdowns in this game. Running back Travis Etienne Jr. is expected to add 59.5 rushing yards and make 2.5 receptions.

Brian Thomas Jr. is a key wide receiver, projected for 69 receiving yards. Brenton Strange, the tight end, could contribute with 34.2 receiving yards. The defense has room for improvement, given their rank in opponent offensive yards last season.

Final Betting Pick

The 49ers are a strong pick for the money line at -174. They have a perfect 3-0 record this season, including a win at home. Their recent home victory against the Cardinals, where they allowed only 15 points, highlights their defensive strength at Levi’s Stadium.

The under 47.0 is a solid choice given both teams’ recent defensive performances. The 49ers allowed only 15 points in their last home game. The Jaguars have also shown defensive capabilities, holding the Texans to just 10 points in their last game. This suggests a lower-scoring game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.