The Kansas City Chiefs will play against the New York Giants on Sunday, September 21, 2025. The game will take place at MetLife Stadium in East Rutherford, NJ, with kickoff at 8:20 PM. Fans can watch the game on NBC. Both teams are looking for their first win of the season.

Chiefs vs. Giants Betting Prediction

• Money Line Prediction: Kansas City Chiefs at -281. The Chiefs have a strong passing game led by Patrick Mahomes. They are looking to bounce back after two close losses.
• Over/Under Prediction: Under 45.5. Both teams have struggled offensively this season, and the Giants’ defense ranks well in sacks, which could limit scoring opportunities.

Team Trends

• The Kansas City Chiefs have an 0-2 record this season, with both losses coming in close games.
• New York Giants also have an 0-2 record this season, including a road loss to the Washington Commanders.
• In their last game, the Chiefs lost to the Philadelphia Eagles 20-17 at home.
• The Giants lost their season opener against the Washington Commanders with a score of 21-6.
• MetLife Stadium in East Rutherford, NJ, will host the game between the Giants and the Chiefs.

Chiefs vs Giants Preview

The Kansas City Chiefs are set to take on the New York Giants in Week 3 of the 2025 NFL season. Both teams are eager to secure their first win of the season. The Chiefs, led by quarterback Patrick Mahomes, are looking to bounce back after two losses. Mahomes is projected to throw for 254.8 yards and 1.7 touchdowns in this game. The Chiefs’ offense will rely on players like Isiah Pacheco and Travis Kelce to make key plays.

The Giants, on the other hand, will depend on Russell Wilson to lead their offense. Wilson is expected to pass for 220.5 yards and score 1.5 touchdowns. Malik Nabers is a key target for Wilson, with a projection of 80 receiving yards. The game at MetLife Stadium is crucial for both teams as they aim to climb out of the bottom of their divisions. Fans can catch the action on NBC at 8:20 PM.

New York Giants: A Look at the Home Team’s Strengths

The New York Giants are led by head coach Brian Daboll. The team plays in the NFC East and calls MetLife Stadium home. They have had a tough start to the season with a 0-2 record.

Quarterback Russell Wilson is a key player for the Giants. He is projected to have 220.5 passing yards and 1.5 touchdowns in this game. Wide receiver Malik Nabers is expected to gain 80 receiving yards and score 0.5 touchdowns.

The Giants’ offense had a challenging last season, finishing 28th in passing yards. On defense, they were ranked 6th in sacks and recovered 10 fumbles. Key players like Rakeem Nuñez-Roches and Andrew Thomas are questionable for this game due to injuries.

Kansas City Chiefs: Analyzing the Away Team’s Key Factors

The Kansas City Chiefs are led by head coach Andy Reid. They play in the AFC West and their home games are at Arrowhead Stadium. This season, they have struggled, sharing the same 0-2 record as the Giants.

Quarterback Patrick Mahomes is a standout player for the Chiefs. He is projected to throw for 254.8 yards and 1.7 touchdowns in this game. Running back Isiah Pacheco is also expected to contribute with 45.7 rushing yards.

The Chiefs’ offense last season ranked 14th in passing yards. On defense, they were ranked 10th in sacks and recovered 7 fumbles. Several players, like Xavier Worthy and Mike Danna, are dealing with injuries and could miss this game.

Final Betting Pick

The Kansas City Chiefs are favored on the money line at -281. Patrick Mahomes leads their passing game with a projection of 254.8 yards and 1.7 touchdowns. Despite two losses, the Chiefs have shown strong offensive potential, especially on the road.

The over/under is set at 45.5, and the under is a solid pick. The Giants have struggled offensively, scoring only 6 points in their last game. Their defense ranks well in sacks, which could limit the Chiefs’ scoring chances, keeping the total points low.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.