Miami Dolphins vs Buffalo Bills NFL Betting Prediction
PublishedSeptember 17, 2025,            Posted By: Maria Uebelhor
Last updated:September 17, 2025 ,

NFL Miami Dolphins vs Buffalo Bills Prediction 9/18

The Miami Dolphins take on the Buffalo Bills on Thursday, September 18, 2025, at 8:15 PM. The game is at Highmark Stadium in Orchard Park, NY, and will be shown on AMZN. The weather is expected to be warm with a clear sky.

Dolphins vs. Bills Betting Prediction

  • Money Line Prediction: Buffalo Bills -806. The Bills are strong at home with a 1-0 record this season. They have also shown solid performance in recent games, including a win against the New York Jets.
  • Over/Under Prediction: Over 49.5. Both teams have shown the ability to score high points in their recent games. The Dolphins scored 27 points in their last game, and the Bills scored 41 points in their home opener.

Team Trends

  • The Buffalo Bills are 2-0 this season, with a home record of 1-0.
  • Miami Dolphins have started the season with a 0-2 record, losing both home and away games.
  • In their last home game, the Buffalo Bills won against the Baltimore Ravens with a score of 41-40.
  • Miami Dolphins lost their last away game against the Indianapolis Colts with a score of 33-8.
  • The game will be played at Highmark Stadium, where the weather is expected to be clear with a light breeze.

Dolphins vs Bills Preview

 

The Miami Dolphins head to Highmark Stadium to take on the Buffalo Bills in Week 3 of the 2025 NFL season. The Dolphins are looking for their first win, sitting at 0-2, while the Bills are at the top of the AFC East with a 2-0 record. This game is crucial for the Dolphins to turn their season around.

Quarterback Tua Tagovailoa leads the Dolphins with a projected 253.5 passing yards and 1.6 touchdowns. On the other side, Josh Allen is expected to throw for 233 yards and 1.7 touchdowns for the Bills. The key matchup will be between the Dolphins’ wide receivers and the Bills’ secondary. Tyreek Hill and Jaylen Waddle will try to break through the Bills’ defense, while the Bills’ offense aims to keep their winning streak alive.

 

Buffalo Bills: Home Team Overview

The Buffalo Bills are led by head coach Sean McDermott. They have a strong start to the season with a 2-0 record. Playing at Highmark Stadium, the team is part of the AFC East division.

Quarterback Josh Allen is a key player for the Bills. He has recorded 542 passing yards and 2 touchdowns in two games this season. This game, Allen is projected to earn 22.3 fantasy points with 233 passing yards and 1.7 touchdowns.

Running back James Cook is another standout player. Cook has 176 rushing yards and 3 touchdowns in the current season. He is expected to gain 67.7 rushing yards and score 0.8 touchdowns in the upcoming game.

Miami Dolphins: Quest for First Win

The Miami Dolphins are looking to improve under head coach Mike McDaniel. They have started the season with a 0-2 record. Playing in the AFC East division, the Dolphins aim to secure their first win on the road.

Quarterback Tua Tagovailoa is a key player for the Dolphins. In two games, Tagovailoa has thrown for 429 yards and 3 touchdowns. For this game, he is projected to have 253.5 passing yards and 1.6 touchdowns, scoring 14.8 fantasy points.

Running back De’Von Achane is another player to watch. Achane has rushed for 85 yards and caught 11 passes in two games. He is expected to add 62.1 rushing yards and 0.5 touchdowns in the upcoming game.

Final Betting Pick

The Buffalo Bills are favored for a reason. They have a strong home record, winning their only home game this season. Their offense is ranked 2nd in scoring from last season, and they scored 41 points in their home opener. This shows they can put up points, especially at home.

The over 49.5 prediction is also supported by both teams’ recent performances. The Bills scored 41 points in their home game, and the Dolphins scored 27 in their last game. Both teams have shown they can score, making the over a solid pick for this game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.