Seattle Seahawks vs San Francisco 49ers NFL Betting Prediction
PublishedDecember 31, 2025,            Posted By: Maria Uebelhor
Last updated:December 31, 2025 ,

NFL Seattle Seahawks vs San Francisco 49ers Prediction 1/3

The Seattle Seahawks take on the San Francisco 49ers on Saturday, January 3, 2026. This Week 18 game is at Levi’s Stadium in Santa Clara, CA, with kickoff at 8:00 PM. Fans can catch the action on ABC, while the weather forecast predicts a mild day with broken clouds and a light breeze.

Seahawks vs. 49ers Betting Prediction

  • Money Line Prediction: Seattle Seahawks -119. The Seahawks have a strong road record of 7-1 this season. They have been consistent in their recent games, making them a good pick.
  • Over/Under Prediction: Over 49.5. Both teams have shown the ability to score high points in recent games. The 49ers scored 42 points in their last home game, and the Seahawks have been scoring well too.

Team Trends

  • The Seattle Seahawks have a strong road record this season, winning 7 out of 8 away games.
  • The San Francisco 49ers have won 5 out of 7 home games this season.
  • Seattle’s offense is led by Sam Darnold, who threw for 249 yards and 3 touchdowns against the Atlanta Falcons.
  • The 49ers’ Brock Purdy passed for 303 yards and 3 touchdowns in their recent win over the Chicago Bears.
  • Christian McCaffrey rushed for 140 yards and scored a touchdown in the 49ers’ last game against the Bears.

Seahawks vs 49ers Preview

The Seattle Seahawks are heading into this game with a strong record of 13-3. They are currently leading the NFC West Division. Their quarterback, Sam Darnold, is expected to throw for 247.5 yards and 1.7 touchdowns. Kenneth Walker III will be key in the running game, projected to gain 59.6 rushing yards.

The San Francisco 49ers, with a 12-4 record, are right behind the Seahawks in the division. Brock Purdy is set to lead their offense with 241.4 passing yards and 1.9 touchdowns. Christian McCaffrey is another crucial player for the 49ers, expected to rush for 64.3 yards and make 4.8 receptions. Both teams are on a six-game winning streak, making this a pivotal game for the division standings.

San Francisco 49ers: Game Day Spotlight

The San Francisco 49ers have a strong lineup for the upcoming game. Quarterback Brock Purdy is projected to gain 241.4 passing yards and score 1.9 touchdowns. Running back Christian McCaffrey is expected to add 64.3 rushing yards and 0.6 touchdowns to the team’s performance.

Head Coach Kyle Shanahan leads the 49ers, who have a current season record of 12-4-0. They have performed well at home with a 5-2-0 record. The 49ers play in the NFC West division and call Levi’s Stadium their home.

In the 2024 season, the 49ers ranked 4th in passing yards with 4234. Their rushing yards ranked 12th with 2163. On defense, they recorded 37 sacks, placing them 12th in the league.

Seattle Seahawks: Preparing for the Next Challenge

The Seattle Seahawks are ready with Sam Darnold leading the offense. Darnold is expected to reach 247.5 passing yards and 1.7 touchdowns. Kenneth Walker III, their primary running back, is projected to rush for 59.6 yards and add 0.4 touchdowns.

Head Coach Mike Macdonald has guided the Seahawks to a solid 13-3-0 record this season. They have been impressive on the road with a 7-1-0 record. In the NFC West division, the Seahawks have secured a 3-2-0 division record.

Last season, the Seahawks ranked 8th in passing yards with 4020 and 27th in rushing yards with 1627. Their defense was strong with 45 sacks, ranking 6th in the league. However, they face some challenges with key players like Cody White and Tory Horton out due to injuries.

Final Betting Pick

The Seattle Seahawks have a strong road record this season, winning 7 out of 8 games. This makes them a reliable choice for the money line prediction. Sam Darnold, their quarterback, is expected to pass for 247.5 yards and 1.7 touchdowns, which could lead the team to another victory.

The over 49.5 prediction is also a good choice. Both teams have been scoring high points recently. The 49ers scored 42 points in their last home game. With players like Jaxon Smith-Njigba projected to gain over 100 receiving yards, the Seahawks can contribute to a high-scoring game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.