Tennessee Titans vs Arizona Cardinals NFL Betting Prediction
PublishedOctober 1, 2025,            Posted By: Maria Uebelhor
Last updated:October 1, 2025 ,

NFL Tennessee Titans vs Arizona Cardinals Prediction 10/5

The Tennessee Titans will play against the Arizona Cardinals on Sunday, October 5, 2025. The game will take place at State Farm Stadium in Glendale, Arizona. Kickoff is set for 4:05 PM, and it will be broadcast on CBS.

Titans vs. Cardinals Betting Prediction

  • Money Line Prediction: Arizona Cardinals at -417. The Cardinals have a better record and are playing at home, where they have been even this season.
  • Over/Under Prediction: Under 41.5 (-113). The Titans have struggled offensively, scoring only 12 points in their last road game.

Team Trends

  • The Tennessee Titans are still looking for their first win this season, with a record of 0-4.
  • The Arizona Cardinals have an even record of 2-2 this season, splitting both their home and away games.
  • In their last away game, the Titans lost to the Houston Texans 26-0, struggling with only 93 passing yards.
  • The Cardinals recently played at home against the Seattle Seahawks, losing a close game 23-20.
  • Arizona’s Kyler Murray has been a key player, throwing for over 200 yards and 2 touchdowns in their last game.

Titans vs Cardinals Preview

 

The Tennessee Titans are looking for their first win of the season as they visit the Arizona Cardinals in Week 5. The Titans are at the bottom of the AFC South with a 0-4 record. Quarterback Cameron Ward is expected to throw for 184.3 yards and 1.1 touchdowns. Running back Tony Pollard aims to add to the offense with 68.2 rushing yards.

The Arizona Cardinals are 2-2 and sit fourth in the NFC West. Quarterback Kyler Murray is projected to pass for 214.7 yards and 1.6 touchdowns. Wide receiver Marvin Harrison Jr. could be a key player with 57.9 receiving yards expected. Both teams hope to improve their standings with a win.

 

Arizona Cardinals Ready for Action at Home

The Arizona Cardinals are set to play with Kyler Murray leading the charge. Murray is expected to throw for 214.7 yards and score 1.6 touchdowns. He has not thrown any interceptions this season.

Trey Benson will be key in the running game, aiming for 73.8 rushing yards. Marvin Harrison Jr. is the top target, projected to receive 57.9 yards and score 0.6 touchdowns. Chad Ryland will be handling the kicking duties, with an expected 1.9 field goals made.

Head Coach Jonathan Gannon is steering the team with a 2-2-0 record so far. The Cardinals are playing in the NFC West division at State Farm Stadium. They aim to improve their 1-1-0 home record this season.

Tennessee Titans Gear Up for Tough Road Test

The Tennessee Titans are led by Head Coach Brian Callahan. They are aiming for their first win of the season with a 0-4-0 record. The Titans play in the AFC South and have struggled on the road, holding a 0-2-0 away record.

Quarterback Cameron Ward is expected to lead the offense. He is projected to throw for 184.3 yards and score 1.1 touchdowns. Ward has not thrown any interceptions this season.

Running back Tony Pollard will be key in the running game, aiming for 68.2 rushing yards. Wide receiver Calvin Ridley is one of the top targets with a projection of 51.7 receiving yards. Kicker Joey Slye is expected to make 1.4 field goals in the game.

Final Betting Pick

The Arizona Cardinals are a strong pick for the money line at -417. They have a better record than the Titans and are playing at home. The Cardinals have shown they can perform well at State Farm Stadium, with a 1-1 home record this season.

The under 41.5 points is a solid choice given the Titans’ recent struggles on offense. They scored only 12 points in their last road game against the Broncos. With the Cardinals’ defense ranked 14th in opponent scoring last season, the Titans may find it hard to score.

From kickoff on Saturdays to the final whistle on Sundays, Action 24/7 is giving you more reasons to cheer. Get a 10% College Football & NFL boost on spreads and totals every game day. Bet your favorites, back your instincts, and boost your winnings with Action 24/7.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.