The Houston Astros (86-73) travel to face off against the Cleveland Guardians (92-67) on Friday, September 27th. This game will be played at Progressive Field in Cleveland and televised on MLBN. The Guardians are coming off a win in their previous game, while the Astros are looking to get back on track from a loss to the Mariners. First pitch is set for 6:10 CT.

Astros vs. Guardians Betting Prediction

• Money Line Prediction: Astros (+103)
• Over/Under Prediction: Over 7.5 Runs

• Astros have won 5 out of their last 7 road games.
• Astros have scored an average of 5.2 runs per game in their last 15 games.
• Astros have a 6-4 record in their last 10 games.
• Astros have a better overall away record (40-38) compared to the Guardians’ home record (42-39).
• Astros have won 4 out of their last 5 games against the Guardians.

Astros vs Guardians

The Guardians Took The Last Game Of This Series

Houston closed out their series vs. the Mariners with a tough 8-1 loss. Heading into the game, the Astros were the +132 underdog on the money line. Things started off well for the Astros, as they got on the board with a run in the 3rd inning but gave up the lead right away as the Mariners scored three times in the top of the 3rd.

Yusei Kikuchi put together a good start for the Astros, going six innings and not giving up a run. He also issued just one walk and struck out eight Mariners. However, the Astros’s offense really struggled after their 1st-inning run, and they didn’t score again. Houston was also the victim of some bad luck, as the Mariners scored three runs in the 3rd on just two hits.

As the favorite, the Astros have a 67-51 record, but as underdogs, they are 19-22. Against the run line, they are 43-35 on the road and 26-15 as underdogs. Houston’s overall run line record is 81-78, with an average run margin of +0.2 per game.

Houston leads the AL West by four games with an 86-73 overall record. Their series record this season is 27-22-2, and the over/under record is 65-88. Today’s O/U line of 7.5 runs is lower than their season average of 8.6 runs per game.

Ronel Blanco Gets The Start For The Astros

Ronel Blanco has been pitching well for the Astros, as he comes into the game with a record of 12-6 and an ERA of 2.88. Blanco’s WHIP for the season is currently 1.10. In his 28 starts, Blanco has one complete game shutout and 14 quality starts. Looking at his numbers, Blanco has been much better on the road, with a record of 6-2, compared to 6-4 at home. His ERA on the road is 2.62, while it is 3.48 at home. Blanco’s last outing came at home, where he gave up two earned runs in six innings of work. He got the win in that outing.

Astros Offense Breakdown

Yordan Alvarez has been the Astros’ top hitter this season, as he is batting .308 and leads the team with 35 home runs and 86 RBIs. Alex Bregman has also been a big power threat for the Astros, as he has 26 homers and has gone deep three times in his past six games while hitting .318 in that stretch. Overall, Bregman is batting .256 for the season.

As a team, the Astros are 3rd in batting average and are averaging 4.6 runs per game. They have been especially good at home, averaging 4.9 runs per contest. Overall, they are 9th in home runs and have the 3rd fewest strikeouts in the league. Houston comes into the game with the league’s 5th best on-base percentage.

The Guardians Are Coming Off A Win

The Guardians wrapped up their series vs. the Reds with a 5-2 win. Leading up to the game, they were the heavy favorite at -146. Offensively, the Guardians scored their five runs on eight hits and only hit two home runs. It was José Ramírez and Steven Kwan doing most of the damage, as they each went 3/4 with a homer.

Andrew Walters got the start for the Guardians but only lasted 1 /3 innings. He didn’t give up a run, but the Reds pulled him in the 2nd inning. Hunter Gaddis got the win out of the bullpen, and Emmanuel Clase picked up the save.

Heading into today’s game, the Guardians have a 92-67 overall record and are leading the AL Central by seven games. They have won two straight and are 7-3 in their last 10 games. Cleveland’s series record is 29-16-6, and they are coming off a 2-0 series win over the Reds.

When favored, the Guardians are 64-34 straight up and 43-21 at home. Against the run line, they are 46-52 as favorites and 39-39 at home. This season, their games have averaged 8.3 runs, and the under has hit in their last three games. The over/under line for today’s game is set at 7.5 runs.

Joey Cantillo Gets The Start For The Guardians

Left-hander Joey Cantillo gets the start for the Guardians today as he faces the Astros at home. He has made seven starts this year and has a record of 2-3 with an ERA of 4.63. Cantillo’s WHIP for the season is currently 1.20. In his last outing, he finished with a no-decision, going 4 1/3 innings and giving up one earned run on six hits. Before that, he had picked up the win in two straight starts. One of those wins was a seven-inning outing in which he gave up just one earned run. Cantillo’s ERA at home is 2.21 compared to 7.48 on the road.

Guardians Offense Breakdown

Jose Ramirez has been swinging a hot bat of late, going 10/24 in his last six games with three homers and eight RBIs. For the season, he is batting .279 with 38 homers and 115 RBIs. His 115 RBIs are 3rd in the league. Josh Naylor is also a power threat in the lineup, as his 31 homers is 2nd on the team and 7th in the MLB.

Overall, the Guardians are averaging 4.4 runs per game and have been a better offensive team at home, where they are averaging 4.7 runs per contest. As a team, they are batting just .238, which is 16th in the league, and are 11th in the league in home runs. So far, they have done a good job of limiting strikeouts but are just 21st in the league in walks.

Astros vs Guardians Prediction

Our prediction for this Astros vs. Guardians matchup is to take the Astros on the money line, with the payout sitting at +103. We actually have the Astros winning this one by a score of 5-4. If you’re looking for a parlay, you could also look to the over/under, where the line is at 7.5 runs. However, we like the payout on the Astros to win straight up.

Looking at the starting pitcher’s projections, Ronel Blanco is predicted to finish with five strikeouts. As for Joey Cantillo, he has the highest strikeout projection at eight. However, we have Cantillo finishing with a 3rd worst ERA among today’s starters.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.