San Francisco Giants vs Arizona Diamondbacks MLB Betting Prediction
PublishedSeptember 15, 2025,            Posted By: Maria Uebelhor
Last updated:September 15, 2025 ,

MLB Francisco Giants vs Arizona Diamondbacks Prediction 9/15

The San Francisco Giants will take on the Arizona Diamondbacks at Chase Field in Phoenix, AZ. The game is set for Monday, September 15, 2025, at 9:40 PM. The Giants hold a record of 75-74, while the Diamondbacks are at 75-75. Both teams are looking to improve their standings in the NL West. Fans can catch the action on NBCS. The weather forecast calls for a very hot day with clear skies, but the retractable roof at Chase Field should keep conditions comfortable.

Giants vs. Diamondbacks Betting Prediction

  • Money Line Prediction: San Francisco Giants +120. The Giants have a balanced road record of 37-37 and offer better value at +120. The Diamondbacks have a slight edge at home but the odds favor the Giants for betting value.
  • Over/Under Prediction: Over 9.0 (-121). Both teams have shown the ability to score runs recently, and with both starting pitchers having high ERAs, the over looks promising.

Team Trends

  • The Arizona Diamondbacks have a home record of 38-34 this season.
  • The San Francisco Giants have a road record of 37-37 this season.
  • In their last game, the Arizona Diamondbacks won 6-4 against the Minnesota Twins.
  • The San Francisco Giants have lost their last two games against the Los Angeles Dodgers.
  • The game will take place at Chase Field in Phoenix, AZ, with a retractable roof.

Giants vs Diamondbacks Preview

The San Francisco Giants are gearing up to play against the Arizona Diamondbacks at Chase Field. The Giants, with a record of 75-74, are third in the NL West. They have lost their last two games and are looking to bounce back. The Giants will rely on Kai-Wei Teng, who has a 7.54 ERA, to lead them on the mound. His performance will be crucial as the team aims to end their losing streak.

On the other side, the Arizona Diamondbacks hold a 75-75 record and are fourth in the division. They have won their last two games and are hoping to continue their winning momentum. Zac Gallen will start for the Diamondbacks. He has an ERA of 4.84 and a record of 11-14. Both teams are eager for a win to improve their standings in the NL West.

Diamondbacks Ready to Shine at Home

The Arizona Diamondbacks have some strong hitters this season. Geraldo Perdomo leads the team with a .286 batting average and 95 RBIs. Ketel Marte is another key player with 25 home runs and a .279 batting average. Zac Gallen will be the starting pitcher for the Diamondbacks. He has an ERA of 4.84 and a WHIP of 1.28. Gallen’s record is 11 wins and 14 losses. The team ranks 7th in batting average and on-base percentage. They are 3rd in slugging percentage with .434 and have hit 203 home runs. The Diamondbacks have a team ERA of 4.47, ranking 23rd in the league.

Giants Aim to Conquer on the Road

The San Francisco Giants have some power hitters in their lineup. Rafael Devers leads the team with 31 home runs and 102 RBIs. Willy Adames also contributes with 28 home runs and 82 RBIs. The team has a batting average of .238, ranking 14th in the league. Matt Chapman adds to the Giants’ offense with 21 home runs. Wilmer Flores and Patrick Bailey have also shown some power. Flores has 15 home runs, while Bailey has 6. The Giants are 17th in slugging percentage with .390. On the mound, Kai-Wei Teng will start for the Giants. Teng has struggled this season with an ERA of 7.54. His record stands at 2 wins and 4 losses. The Giants’ team ERA is 3.86, ranking 9th in the league.

Final Betting Pick

The San Francisco Giants are a solid pick for the money line at +120. Their road record of 37-37 shows they can compete away from home. With Kai-Wei Teng starting, the Giants will need to rely on their hitters like Rafael Devers, who leads the team in home runs and RBIs.

The over 9.0 runs is a strong choice because both teams have been scoring well. The Giants recently scored 7 runs against the Dodgers, while the Diamondbacks scored 6 against the Twins. With both starting pitchers having high ERAs, runs are likely in this game.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.