Houston Astros vs St. Louis Cardinals MLB Betting Prediction
PublishedApril 16, 2025,            Posted By: Maria Uebelhor
Last updated:April 16, 2025 ,

MLB Houston Astros vs St. Louis Cardinals Prediction 4/16

The Houston Astros will play against the St. Louis Cardinals at Busch Stadium. This game is scheduled for Wednesday, April 16, 2025. Fans can catch the action starting at 1:15 PM under the lights.

Astros vs. Cardinals Betting Prediction

  • Money Line Prediction: Cardinals MoneyLine: -104. The Cardinals have a strong hitting lineup with the highest team batting average and on-base percentage. This gives them an edge against the Astros’ pitching.
  • Over/Under Prediction: Under 8.5 (-114). Both teams have solid pitching, with the Astros ranking high in ERA and batting average against. This may lead to a lower-scoring game.

Team Trends

  • Both the Houston Astros and St. Louis Cardinals have a season record of 8-9, with each team being 2 games back in their respective divisions.
  • The Astros have an even road record of 4-4, while the Cardinals struggle on the road with a 1-5 record.
  • In a recent spring training game on April 15, 2025, the Astros defeated the Cardinals 2-0, with Hunter Brown allowing no runs in 6 innings.
  • During their recent win over the Cardinals, Astros player Yordan Alvarez hit a home run, contributing to the team’s victory.
  • The Cardinals had a strong performance against the Phillies on April 13, 2025, winning 7-0 with Matthew Liberatore allowing no runs in 6 innings.

Astros vs Cardinals Preview

The Houston Astros are set to meet the St. Louis Cardinals at Busch Stadium. This game will take place on Wednesday, April 16, 2025. The first pitch is scheduled for 1:15 PM under the night sky.

Ronel Blanco will start for the Astros. He has a 1-1 record this season with an ERA of 6.94 over 11 2/3 innings. The Cardinals will counter with Steven Matz, who has an ERA of 2.31 in 11 2/3 innings. Matz has not started a game this season, but he has appeared in five games.

Cardinals Ready for Action

The St. Louis Cardinals have shown strong hitting skills this season. Brendan Donovan leads the team with a .382 batting average. He also tops the league with 11 RBIs. Lars Nootbaar and Nolan Arenado are also key players, each with 2 home runs. The Cardinals excel in team hitting, ranking first in batting average and on-base percentage. They have hit 19 home runs, placing seventh in the league. Their slugging percentage is fourth, showing their power at the plate. On the pitching side, Steven Matz has an ERA of 2.31 in 11 2/3 innings. The team pitching has a 4.25 ERA, ranking 19th. They have allowed only 12 home runs, ranking third in the league.

Astros Set to Compete

The Houston Astros have a few standout players this season. Jeremy Peña, Jose Altuve, and Isaac Paredes each have 3 home runs. Altuve and Peña have both scored 10 runs, leading the team. The Astros’ team batting average is .219, placing them 15th in the league. They have 14 home runs, ranking 12th. Their on-base percentage sits at .306, which ranks 17th. On the mound, Ronel Blanco is the starting pitcher for the Astros. Blanco has pitched 11 2/3 innings this season with an ERA of 6.94. He has recorded 11 strikeouts in his appearances.

Final Betting Pick

The Cardinals’ MoneyLine at -104 looks favorable due to their strong batting lineup. They lead in team batting average and on-base percentage, which could challenge the Astros’ pitching. The Cardinals’ hitters like Brendan Donovan and Nolan Arenado have impressive stats, adding to their offensive strength.

The under 8.5 prediction is supported by both teams’ solid pitching. The Astros have a low ERA and a high batting average against, indicating effective pitching. Steven Matz of the Cardinals has a low ERA of 2.31, which could keep the game low-scoring. Both teams’ recent games also show a trend of lower scores, reinforcing the under pick.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.