The Chicago White Sox (36-118) travel to face off against the San Diego Padres (88-66) on Saturday, September 21st. This game will be played at PETCO Park in San Diego and televised on NBCS. The Padres are coming off a win in their previous game, while the White Sox are looking to get back on track from a loss to the Padres. First pitch is set for 7:40 CT.

White Sox vs. Padres Betting Prediction

• Money Line Prediction: Padres (-272)
• Over/Under Prediction: Over 8 Runs

• Padres have won 10 of their last 15 games.
• Padres have a home record of 43-36, while the White Sox have an away record of 16-60.
• Padres have outscored their opponents 55-34 in their last 10 home games.
• Padres have a league rank of 4th, while the White Sox are ranked 15th in their league.
• Padres have a winning streak of 2 games, while the White Sox are on a 3-game losing streak.

White Sox vs Padres

San Diego picked up a 3-2 win over the White Sox in the most recent game of this series. The Padres had a two-run lead heading into the 9th inning, and the White Sox scored their only two runs in the top of the 9th. Chicago had a chance to tie or take the lead, but the Padres closed things out for the win.

Joe Musgrove started for the Padres and picked up the win, going six innings and not giving up a run. He finished the game with nine strikeouts but didn’t issue a walk. Garrett Crochet only went four innings for the White Sox, giving up two earned runs on one hit.

Jake Cronenworth went 3/3 with two runs scored for the Padres, while Xander Bogaerts also had two hits and an RBI. Jackson Merrill drove in two runs while going 1/3.

Chicago has struggled this season, with an overall record of 36-118 and a 3-7 record in their last 10 games. They are currently 5th in the AL Central, 53.5 games behind the Guardians. As underdogs, the White Sox have a 31-115 record, and as road underdogs, they are 16-59.

On the run line, the White Sox are 32-44 on the road and 58-88 as underdogs. Their over/under record this season is 65-81, and when the O/U line is set at 8 runs, their record is 13-14-3. Today, the O/U line is 8 runs, and their current under streak is at 3 games.

Chris Flexen Gets The Start For The White Sox

Chris Flexen will be looking to bounce back from a short outing, as he gets the start for the White Sox today. In his most recent outing, Flexen went just 5 innings and didn’t give up a run, finishing with a no-decision. He was much better in that outing compared to his previous start, where he gave up 3 earned runs in 3 1/3 innings of work. Flexen’s record for the season is 2-14, and his ERA is 5.08. Opposing batters are hitting .276 off Flexen this season. Out of his 28 starts, Flexen has turned in 9 quality starts.

White Sox Offense Breakdown

Chicago’s offense has been one of the worst in the league this season, as they are dead last in home runs and near the bottom of the league in batting average, on-base percentage, and slugging. For the season, they are averaging just 3.1 runs per game, which is the worst mark in the league. Their team ISO of .119 is also the worst in the MLB.

Andrew Vaughn and Andrew Benintendi are tied for the team lead in home runs, with 19, but both players are batting under .250 for the season. However, Benintendi has been swinging the bat well of late, going 9/34 in his last nine games with three homers. Lenyn Sosa has also been hot, batting .387 over his last eight games.

San Diego is 88-66 overall and 2nd in the NL West, four games behind the Dodgers. The Padres have won two straight games and are 7-3 in their last 10. Their over/under record is 80-71, and games have averaged 8.9 runs per game this season.

As the underdog, the Padres have a run line record of 37-17, but as the favorite, they are 41-59 vs. the run line. At home, they are 43-36 straight up and 31-48 against the run line, with an average run margin of -0.0.

Martín Pérez Gets The Start For The Padres

Left-hander Martín Pérez gets the start for the Padres today as he faces the White Sox at home. So far this season, he has made 24 starts and has a record of 4-5 with an ERA of 4.36. Looking at his overall numbers, Perez has a WHIP of 1.47 and has issued 3.14 walks per nine innings compared to 7 strikeouts. Perez has made eight quality starts this year and is coming off an outing in which he gave up one earned run in five innings of work. He finished with a no-decision in that outing. Before that, he had given up at least four earned runs in three straight starts.

Padres Offense Breakdown

San Diego comes into the game with the league’s top batting average at .265 and is also one of the top home run hitting teams in the league. Overall, they are averaging 4.7 runs per game, which is 8th in the league. The Padres have been even better on the road this season, averaging 5.1 runs per contest.

Manny Machado has been on a tear of late, going 9/25 with three homers over his last six games. This has pushed his season average to .279, and he is 7th in the league with 104 RBIs. Machado is also on a four-game hitting streak. Jackson Merrill has also been a big power threat for the Padres, as his 24 homers is 2nd on the team.

White Sox vs Padres Prediction

The best bet for today’s White Sox vs. Padres matchup is to take the over, with the line currently sitting at 8 runs. Our predicted final score is 6-5 in favor of the Padres, giving us some wiggle room if you wanted to take the money line.

Looking at the starting pitchers, we have Chris Flexen going 3 innings and finishing with four strikeouts. As for Martín Pérez, we have him going six innings and finishing with just three K’s. If you’re looking for a player prop bet, you could look to take the over on Flexen’s strikeout total.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.