The Chicago White Sox (36-119) travel to face off against the San Diego Padres (89-66) on Sunday, September 22nd. This game will be played at PETCO Park in San Diego and televised on None. The Padres are coming off a win in their previous game, while the White Sox are looking to get back on track from a loss to the Padres. First pitch is set for 3:10 CT.

White Sox vs. Padres Betting Prediction

• Money Line Prediction: Padres (-310)
• Over/Under Prediction: Over 7.5 Runs

• Padres have won 10 out of their last 15 games.
• Padres have a home record of 44-36, while the White Sox have an away record of 16-61.
• Padres have outscored their opponents 59-34 in their last 15 games.
• Padres have won their last 3 games against the White Sox, scoring 12 runs and allowing only 4.
• Padres have a league rank of 3rd in the NL West, while the White Sox are last in the AL Central.

White Sox vs Padres

San Diego picked up a 6-2 win over the White Sox in the most recent game of this series. The Padres had a huge 2nd inning, scoring all six of their runs. As for the White Sox, they scored their only two runs in the 4th. Heading into the game, the Padres were favored at -316 on the money line.

Martin Perez only went 5 1/3 innings for the Padres but gave up just one run and picked up the win. He finished the game with six strikeouts but issued three walks. On the other side, Chris Flexen got the start for the White Sox and took the loss, giving up four earned runs in five innings of work.

Elias Diaz and David Peralta each homered for the Padres, while Xander Bogaerts scored twice and drove in two runs while going 1/4. Jackson Merrill also had a two-hit game and drove in a run for San Diego’s offense.

Chicago has struggled as the underdog this season, posting a 31-116 record, and they have lost four straight games in that role. Overall, the White Sox are 7-41-2 in series this year, and they are 36-119, placing them 5th in the AL Central, 53.5 games behind the Guardians.

Against the run line, the White Sox have a 63-92 record, including 32-45 on the road. Their games have averaged 8.2 runs this season, resulting in a 65-81 over/under record. For games with a total of 7.5 runs, the O/U record is 12-19.

Sean Burke Gets The Start For The White Sox

Sean Burke will be making his first road start of the season for the White Sox, as they take on the Padres. Burke has made two appearances this season, with his most recent outing being a win vs. the Athletics. In that start, he went 5 innings, giving up 2 earned runs on 5 hits.

White Sox Offense Breakdown

For the White Sox to get their offense going, they will need Andrew Vaughn and Andrew Benintendi to keep up their recent power surge. Both players have 19 homers this season, which is the best mark on the team. Vaughn is batting .246 for the season, while Benintendi comes in at just .226. Lenyn Sosa has been swinging a hot bat of late, going 9/22 in his last six games.

Chicago’s offense has been one of the worst in the league this season, as they are averaging just 3.1 runs per game. This is also the worst mark in the league. As a team, they are batting just .221 and have an on-base percentage of only .279.

San Diego is 2nd in the NL West, trailing the Dodgers by three games, with an 89-66 record. They are on a three-game winning streak and lead their series vs. the White Sox 2-0. The Padres are 59-42 as favorites and 30-24 as underdogs this season.

On the run line, the Padres have been strong on the road with a 47-28 record but have struggled at home, going 32-48. Their games have averaged 8.9 runs, resulting in an 80-71 over/under record for the season. Their average run differential in wins is +3.6 and -3.5 in losses.

Yu Darvish Gets The Start For The Padres

Yu Darvish will be looking to build off his last outing, where he didn’t give up a run. In that start vs. the Astros, he went six innings and didn’t give up a run. He gave up just three hits in that outing. Darvish has been pitching well lately, as he has a record of 6-3 and an ERA of 3.21. Opposing batters are hitting .218 off Darvish this season. Looking back at his last three outings, he has given up two earned runs in two of those starts. Darvish has made four quality starts this year.

Padres Offense Breakdown

Over the past eight games, the Padres have had three hitters with a good stretch at the plate. Fernando Tatis Jr. has gone 12/34 with three homers, and Jackson Merrill has gone 13/30 with one home run. Manny Machado has also been hot, going 11/34 with three homers and 10 RBIs. Machado’s 104 RBIs are 8th best in the league, and his 29 homers lead the team.

As a team, the Padres are the top hitting team in the league, batting .266, and are also 8th in scoring (4.7 runs per game). They have been even better on the road, averaging 5.1 runs per contest. Overall, they are 9th in home runs and have the best team slugging percentage in the league. The Padres also have the fewest strikeouts in the league.

White Sox vs Padres Prediction

There are a couple of ways you can look to play this game, but we are going to recommend taking the over, as there is some good value with the line sitting at 7.5 runs. Our predicted score is 5-4 in favor of the Padres, giving us some wiggle room on the over/under line.

If you are looking for a moneyline pick, we would go with the Padres, as they are our predicted winner and you could parlay this with the over to increase your payout.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.