The Buffalo Bills will face off against the Indianapolis Colts at 1:00 ET on Sunday, November 10th. This matchup is being played at Lucas Oil Stadium in Indianapolis.

The Colts, who are the underdog at +171 on the money line, will host the Buffalo Bills at 1:00 ET on Sunday, November 10th at Lucas Oil Stadium. The Bills are favored on the road with a point spread of -4. Buffalo is favored on the road with a point spread of -4, and the Bills are -205 on the money line. This week 10 AFC matchup will be televised on CBS.

• Date: Sunday, November 10th
• Time: 1:00 ET
• Location: Lucas Oil Stadium, Indianapolis
• TV: CBS

Bills vs Colts

Buffalo heads into week 10 on a four-game winning streak, including a 30-27 home victory over the Dolphins in week 9. The Bills couldn’t cover the 6-point spread, but the 57 combined points went over the 49-point line. Before that, they picked up a 21-point win over the Seahawks in week 8 and beat the Titans 34-10 in week 7. They also have a 23-20 win over the Jets during their current streak.

With a 7-2 record, Buffalo sits 1st in the AFC East and 2nd in the conference. Our projections give them a 98.5% chance of winning the division and a 99.6% chance of making the playoffs. The Bills rank 4th in our NFL power rankings and have an average scoring margin of +9.7 points per game. They are 5-4 against the spread this season.

After a week 7 win over the Dolphins, the Colts have now dropped two straight, including a 21-13 loss to the Vikings in week 9. This puts their record at 4-5, leaving them 2nd in the AFC South. They are 1-3 in division games and 3-3 in conference play. Our projections give them a 37.2% chance of making the playoffs and a 9.7% chance of winning the division.

Heading into week 10, the Colts are 21st in our power rankings. Despite their losing record, they are 7-2 against the spread, including 5-1 as underdogs. Their O/U record is 3-6, with the under hitting in four straight games.

Bills Injury Report

• DeWayne Carter – Wrist (Out)
• Travis Clayton – Shoulder (Out)
• Tylan Grable – Groin (Out)
• Keon Coleman – Wrist (Questionable)
• Christian Benford – Wrist (Questionable)
• Reggie Gilliam – Hip (Questionable)
• Tommy Doyle – Undisclosed (Out)
• Shane Buechele – Neck (Out)
• Casey Toohill – Knee (Questionable)
• Matt Milano – Bicep (Out)
• Dawuane Smoot – Wrist (Out)
• Amari Cooper – Wrist (Questionable)

Colts Injury Report

• Ryan Coll – Undisclosed (Out)
• Jaylon Carlies – Ankle (Out)
• Daniel Scott – Achilles (Out)
• JuJu Brents – Knee (Out)
• Wesley French – Ankle (Out)
• Trevor Denbow – Knee (Out)
• Bernhard Raimann – Concussion (Questionable)
• Jelani Woods – Toe (Out)
• Will Fries – Tibia (Out)
• Samson Ebukam – Achilles (Out)
• Tyquan Lewis – Elbow (Out)
• Juwann Winfree – Undisclosed (Out)

Bills Offense Breakdown

Josh Allen has been playing well, with passer ratings of 95 in week 9, 102 in week 8, and 116 in week 7. In his week 9 game against the Dolphins, he threw for 235 yards and 3 touchdowns on 25/39 passing. James Cook led the rushing attack with 44 yards on 10 carries, while Ray Davis had 70 receiving yards on 2 catches, including a touchdown.

Heading into week 10, the Bills are 4th in our offensive power rankings. They are also 4th in the NFL in points per game, averaging 28.9. However, they rank 15th in 3rd-down conversions and 28th in red zone conversion percentage, despite being 2nd in red zone attempts.

Colts Offense Breakdown

Heading into week 10, the Colts rank 23rd in our offensive power rankings, averaging 20.9 points per game (21st) and 315 total yards per game (22nd). They are 20th in both passing attempts (29.9) and rushing attempts (26.1) per game, with 193.7 passing yards per game (22nd) and 121.3 rushing yards per game (16th). On third downs, they rank 19th with a 36.6% conversion rate, and they are 12th in red zone conversion percentage, despite being 11th in red zone attempts. The Colts have been strong in the first quarter, ranking 9th in the NFL in points scored.

In week 9, Indianapolis scored 13 points in their loss to the Vikings, with Joe Flacco throwing for 179 yards on 16/27 passing, with one interception. Jonathan Taylor led the team with 48 rushing yards on 13 carries, while Josh Downs had 6 receptions for 60 yards. The Colts did not have any red zone attempts and converted 3 of 11 third downs.

Bills Team Defense

In their 30-27 win over the Dolphins, the Bills’ defense allowed 373 total yards. Miami found some success running the ball, gaining 149 yards on 31 attempts (4.8 yards per attempt). Buffalo’s run defense was a bit of an issue, but they did limit the Dolphins to 224 passing yards on 25 completions.

Buffalo allowed Miami to convert on 50% of their third down attempts and gave up two passing touchdowns. The Bills’ defense managed just one sack in the game.

Colts Team Defense

In their 21-13 loss to the Vikings, the Colts’ defense gave up 415 yards and struggled to defend the pass, allowing three touchdowns through the air. Despite this, they did manage to come up with two interceptions. Minnesota found success on the ground as well, rushing for 133 yards on 32 attempts.

Indianapolis allowed the Vikings to complete 82.9% of their passes and convert on 50% of their third down attempts. On a positive note, the Colts’ defense recorded four sacks and had four more tackles for loss than the Vikings.

Bills vs Colts Trends

• When looking at their past three road matchups, Buffalo has an ATS record of 2-1 while averaging 24 per game. The team went 2-1 overall in these games.
• Across their last three home contests, Indianapolis has a 2-1 record vs the spread. Their overall mark in these games was 1-2, while averaging 17 points per game.
• Going back to their previous three games as the underdog, Indianapolis has an ATS mark of 2-1 while going 1-2 straight up.
• In their last ten games as the betting favorite, the Bills have a straight up record of 9-1 and an ATS mark of 6-4.

Bills vs Colts Prediction

For this week 10 matchup between the Bills and Colts, we have the Colts coming out on top by a score of 24-22. With the point spread sitting at -4 in favor of the Colts, we like them to not only win but also cover as home underdogs.

As for an over/under pick, with the line at 46 points, we are leaning towards taking the under, as our projections have these teams finishing with 46 combined points.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.