The Arizona Cardinals will face off against the San Francisco 49ers at 4:05 ET on Sunday, October 6th. This matchup is being played at Levi’s Stadium in Santa Clara.

The 49ers are heavily favored in their week five matchup against the Cardinals, with their money line sitting at -358. The game, which kicks off at 4:05 ET, will be played at Levi’s Stadium in Santa Clara, CA. On the point spread, the 49ers are -7.5, and the over/under line is 49.5 points. You can catch this one on FOX.

• Date: Sunday, October 6th
• Time: 4:05 ET
• Location: Levi’s Stadium, Santa Clara
• TV: FOX

Cardinals vs 49ers

The Cardinals’ record is now 1-3 following a 42-14 loss to the Commanders. Arizona was favored by -3.5 but lost by 28 points. The combined 56 points exceeded the over/under line of 48.5 points. Arizona’s only touchdown came early, with Kyler Murray connecting with Marvin Harrison Jr. for a score. The game was tied 7-7 after the 1st quarter, but Washington dominated from there.

Washington scored 10 unanswered points in the 2nd quarter and added a touchdown in the 3rd quarter. Arizona added a touchdown late in the 3rd quarter with a 6-yard run from James Conner but still trailed 27-14 heading into the 4th. The Commanders put the game out of reach in the 4th quarter by outscoring the Cardinals 15-0.

After their 30-13 win over the Patriots, the 49ers are now sitting at 2-2. San Francisco took a 17-point victory, with the over/under line set at 42 points. Heading into the game, the 49ers were 10.5-point favorites, and they covered the spread with their 17-point win.

The 49ers jumped out to an early 6-0 lead after a couple of field goals in the 1st quarter. Brock Purdy and Brandon Aiyuk connected for a touchdown to extend their lead. The Patriots managed a field goal in the 2nd quarter, and the 49ers added two more touchdowns before halftime. Although the Patriots found the endzone twice in the 4th quarter, the game was already out of reach.

Cardinals Injury Report

• Zay Jones – Suspension (Out)
• Justin Jones – Triceps (Out)
• Jonah Williams – Knee (Out)
• Jackson Barton – Toe (Out)
• Carter O’Donnell – Undisclosed (Out)
• Khyiris Tonga – Knee (Questionable)
• Trey McBride – Concussion (Questionable)
• BJ Ojulari – Knee (Out)
• Elijah Jones – Heel (Out)
• Christian Jones – Ankle (Out)
• Darius Robinson – Calf (Out)

49ers Injury Report

• Dre Greenlaw – Achilles (Out)
• Fred Warner – Ankle (Questionable)
• Javon Hargrave – Triceps (Out)
• George Kittle – Ribs (Questionable)
• Christian McCaffrey – Calf/achilles (Out)
• Jon Feliciano – Knee (Out)
• Jordan Elliott – Knee (Questionable)
• Elijah Mitchell – Hamstring (Out)
• Curtis Robinson – Knee (Out)
• Talanoa Hufanga – Ankle (Questionable)
• Ambry Thomas – Forearm (Out)
• Drake Jackson – Knee (Out)
• Kalia Davis – Knee (Out)
• Jacob Cowing – Shoulder (Questionable)
• Ricky Pearsall – Back (Out)
• Kyle Juszczyk – Shoulder (Questionable)

Cardinals Offense Breakdown

Despite the Cardinals rushing for 181 yards on 32 attempts, they struggled in the passing game in their 42-14 loss to the Washington Commanders. Kyler Murray threw for just 115 yards, completing 16 of 22 passes. He was also sacked four times. Murray did connect on one touchdown pass, and his passer rating was 104.

James Conner ran for 104 yards to lead Arizona, averaging 5.8 yards per attempt and scoring one touchdown. On the receiving end, Marvin Harrison Jr. led the team with 45 yards and a touchdown, while also adding five catches.

49ers Offense Breakdown

The 49ers’ offense put up 30 points in their 30-13 win over the Patriots, racking up 283 yards through the air. They also found success on the ground, with 148 rushing yards on 32 attempts. The offense picked up 19 first downs and went 6-of-13 on third down.

Quarterback Brock Purdy threw for 288 yards and completed 15 of 27 passes, with one touchdown and one interception. Jordan Mason led the ground game with 123 yards on 24 carries, including a long run of 25 yards. Jauan Jennings was the top receiver, finishing with 88 yards through the air.

Cardinals Team Defense

In their 42-14 loss to the Washington Commanders, the Cardinals’ defense struggled to stop the run, giving up 216 yards on the ground across 37 attempts. Despite this, they did manage one interception and held Washington to 233 passing yards. However, the Commanders found success on 75% of their third down attempts.

Arizona’s defense couldn’t generate much pressure, finishing with zero sacks and losing the tackles for loss battle by a margin of -2. The Commanders were able to complete 86.7% of their passes and averaged 7.8 yards per attempt.

49ers Team Defense

In their most recent game, the 49ers’ defense was dominant, holding the Patriots to just 143 yards passing in their 30-13 win. They were also tough against the run, allowing only 73 yards on 24 attempts. The defense came up with six sacks and limited New England to a 31.2% conversion rate on third down.

Despite giving up one passing touchdown, the 49ers’ secondary made life difficult for the Patriots, allowing just 19 completions and holding them to a completion percentage of 59.4%. Additionally, San Francisco came away with one interception and had a good day in the passing game, allowing only 4.5 yards per attempt.

Cardinals vs 49ers Trends

• Across their last five road contests, Arizona has a 4-1 record vs the spread. Their overall mark in these games was 2-3, while averaging 23 points per game.
• Through their last three home games, San Francisco has an ATS record of just 0-3. However, their overall record was 0-3 while averaging 21 points per game.
• Looking back on the team’s last three games as the underdog, the Cardinals have a straight up record of 0-3. Their record vs the spread in these games was 2-1.
• Going back to their last three games as the favorite, the 49ers have a straight up record of 1-2. But, their mark vs the spread was just 1-2.

Cardinals vs 49ers Prediction

For this week five matchup between the 49ers and Cardinals, we have the 49ers coming out on top by a score of 31-22. Despite the point spread being at 7.5 in favor of the Cardinals, our pick is to take the 49ers to cover as home favorites.

As for the over/under, with the line sitting at 49.5 points, we like the over, projecting a combined score of 53 points. This could be a good spot to get some action down on the over before kickoff.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.