The Carolina Panthers will play against the Arizona Cardinals on Sunday, September 14, 2025. The game will take place at State Farm Stadium in Glendale, AZ, with a retractable roof. Fans can watch the game on CBS at 4:05 PM.

Panthers vs. Cardinals Betting Prediction

• Money Line Prediction: Arizona Cardinals -297. The Cardinals have a strong start to the season with a win and are playing at home. The Panthers struggled in their first road game.
• Over/Under Prediction: Under 44.5. Both teams showed modest scoring in their first games, with the Panthers scoring 10 points and the Cardinals 20 points.

Team Trends

• The Carolina Panthers are led by head coach Dave Canales.
• The Panthers lost their first game of the season to the Jacksonville Jaguars, 26-10.
• The Arizona Cardinals won their first game of the season against the New Orleans Saints, 20-13.
• The Cardinals’ head coach is Jonathan Gannon.
• This game will be played at State Farm Stadium, which has a retractable roof.

Panthers vs Cardinals Preview

The Carolina Panthers are set to take on the Arizona Cardinals in Week 2 of the 2025 NFL season. The Panthers are looking to bounce back after a loss in their opening game. They are currently at the bottom of the NFC South standings. On the other hand, the Cardinals are riding high with a win and are in second place in the NFC West. The game will be held at State Farm Stadium, where the retractable roof will keep conditions consistent.

Key players to watch include Panthers quarterback Bryce Young, who is projected to throw for over 200 yards. Chuba Hubbard will aim to make an impact on the ground with a projected 73 rushing yards. For the Cardinals, Kyler Murray is expected to lead the offense with over 225 passing yards. Marvin Harrison Jr. will be a target in the passing game, looking to add to his receiving yards. The matchup will be broadcast on CBS at 4:05 PM.

Arizona Cardinals: Home Team Spotlight

The Arizona Cardinals are ready for another game at State Farm Stadium. Jonathan Gannon leads the team as the head coach. They are currently holding a 1-0 record this season.

Kyler Murray is the top quarterback for the Cardinals. He is expected to earn 18.6 fantasy points, with projections of 227.5 passing yards and 1.5 touchdowns. James Conner leads the rushing game with a projection of 67.3 rushing yards.

The Cardinals’ passing attack is supported by Marvin Harrison Jr. and Trey McBride. Harrison Jr. is projected to have 63.4 receiving yards and 0.5 touchdowns. McBride is projected to add 68.5 receiving yards and 0.3 touchdowns.

Carolina Panthers: Road Team Overview

The Carolina Panthers are on the road and looking to secure a win. Head coach Dave Canales leads the team. They have a current season record of 0-1. Their previous road game also ended in a loss.

Bryce Young is the starting quarterback for the Panthers. He is projected to earn 14.6 fantasy points. Young could throw for 205.7 yards and 1.3 touchdowns in the game.

Chuba Hubbard is the top running back for Carolina. He is expected to run for 73.4 yards and score 0.6 touchdowns. The Panthers rely on Hubbard’s performance to boost their running game.

Final Betting Pick

The Cardinals are a good pick for the money line at -297. They had a strong start with a win and are playing at home. Their defense showed strength by allowing only 13 points in their first game. The Panthers, on the other hand, struggled on the road, scoring just 10 points in their opening game against the Jaguars.

Choosing the under 44.5 is also a good bet. Both teams had modest scoring in their first games. The Panthers only managed 10 points, while the Cardinals scored 20. With both teams showing limited offensive output, a lower-scoring game is likely.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.