Los Angeles Chargers vs Arizona Cardinals NFL Betting Prediction

NFL Chargers vs Arizona Cardinals Prediction 10/21/2024

The Los Angeles Chargers will face off against the Arizona Cardinals at 9:00 ET on Monday, October 21st. This matchup is being played at State Farm Stadium in Glendale.

ESPN will broadcast the week seven non-conference matchup between the Chargers and Cardinals on Monday, October 21st at 9:00 ET. The game, being played at State Farm Stadium in Glendale, AZ, has the Chargers favored on the road with a point spread of -2.5. The Chargers’ money line odds are -147, while the Cardinals’ odds are +123. The over/under line is set at 43.5 points.

  • Date: Monday, October 21st
  • Time: 9:00 ET
  • Location: State Farm Stadium, Glendale
  • TV: ESPN

Chargers vs Cardinals

los angeles chargers nfl

With a 3-2 record, the Chargers have a 58.2% chance of making the playoffs and a 4.6% chance of winning the AFC West. They rank 20th in our NFL power rankings. Against the spread, Los Angeles is 3-1-1, including a 3-0 mark as a favorite. Their O/U record is 1-4, with their games averaging 31.4 points compared to an average line of 38.7.

In week 6, the Chargers snapped a two-game losing streak by beating the Broncos 23-16. They covered the 3-point spread, bringing their record to 3-2. Before that, they had lost to the Chiefs in week 4 and the Steelers in week 3. Their last win before the Broncos was a 26-3 victory over the Panthers in week 2.

Heading into week 7, the Cardinals sit at 2-4, with both of their wins coming in division games. After beating the 49ers in week 5, Arizona couldn’t keep the momentum going, losing 34-13 to the Packers in week 6. The Cardinals were 5.5-point underdogs in that game but couldn’t cover the spread, and the 47 combined points resulted in a push on the 47-point O/U line.

According to our projections, the Cardinals have a 24.7% chance of making the playoffs and a 20.5% chance of winning the NFC West. They rank 19th in our NFL power rankings. Arizona has an average scoring margin of -5 points per game and is 3-3 against the spread this season. Their O/U record is 3-2-1, with their games averaging 49.3 points (48.2-point average O/U line).

Chargers Injury Report

  • Kristian Fulton – Hamstring (Questionable)
  • Asante Samuel Jr. – Shoulder (Out)
  • Chris Rumph II – Foot (Out)
  • Gus Edwards – Ankle (Out)
  • Hayden Hurst – Groin (Questionable)
  • DJ Chark – Hip (Out)
  • Joey Bosa – Hip (Questionable)
  • Deane Leonard – Hamstring (Questionable)
  • Ja’Sir Taylor – Fibula (Questionable)
  • Bucky Williams – Undisclosed (Out)
  • Tyler McLellan – Undisclosed (Out)
  • Chris Collins – Undisclosed (Out)

Cardinals Injury Report

  • Matt Prater – Left Knee (Questionable)
  • Angelo Blackson – Undisclosed (Out)
  • Zay Jones – Hamstring (Questionable)
  • Will Hernandez – Knee (Out)
  • Justin Jones – Triceps (Out)
  • Bilal Nichols – Stinger (Questionable)
  • Kyzir White – Knee (Questionable)
  • Evan Brown – Ankle (Questionable)
  • Jonah Williams – Knee (Out)
  • Jackson Barton – Toe (Out)
  • Sean Murphy-Bunting – Neck (Questionable)
  • Carter O’Donnell – Undisclosed (Out)
  • Joey Blount – Hamstring (Questionable)
  • BJ Ojulari – Knee (Out)
  • Marvin Harrison Jr. – Concussion (Questionable)
  • Elijah Jones – Heel (Out)
  • Christian Jones – Ankle (Questionable)
  • Darius Robinson – Calf (Out)

Chargers Offense Breakdown

Heading into week 7, the Chargers are 23rd in our offensive power rankings, scoring 18.2 points per game. They rank 28th in the NFL with 281 passing yards per game and 29th in passing attempts (25.4) and passing yards (153.2). However, they are 10th in rushing yards per game (127.8) on 30.6 attempts per game, which ranks 7th in the league. Los Angeles has been strong in the red zone, converting 91.7% of their opportunities, which ranks 3rd in the NFL.

Justin Herbert threw for 237 yards and a touchdown in week 6, completing 21 of 34 passes without an interception. J.K. Dobbins rushed for 96 yards on 25 carries, while Simi Fehoko led the team with 44 receiving yards. The Chargers scored 20 points in the first half against Denver and converted 11 of 18 third downs.

Cardinals Offense Breakdown

arizona cardinals

Kyler Murray bounced back in week 6, posting a passer rating of 97 with 214 yards and a touchdown on 22/32 passing, after a 195-yard, 1-interception game in week 5. He avoided turnovers and sacks against the Packers. Arizona’s run game struggled in week 6, with Trey Benson leading the team with just 26 yards on 5 carries. Trey McBride led the receiving corps with 8 catches for 96 yards.

Heading into week 7, the Cardinals rank 16th in our offensive power rankings. They are 15th in the NFL in both points (22.2) and yards (332.2) per game. Arizona’s passing attack ranks 24th, averaging 187 yards per game, while their rushing game is 7th in the league, with 145.2 yards per game.

Chargers Team Defense

In their 23-16 win over the Broncos, the Chargers’ defense allowed just a 27.3% conversion rate on third down. They held Denver to 110 yards on 18 rushing attempts, but did give up two rushing touchdowns. The Chargers’ defense also forced one interception and allowed just 206 yards passing.

Los Angeles gave up 316 total yards and allowed the Broncos to complete just 57.6% of their passes. They finished with two sacks but lost the tackles for loss battle with -3 compared to Denver.

Cardinals Team Defense

In their 34-13 loss to the Packers, the Cardinals struggled to defend the pass, giving up 258 yards through the air and allowing four passing touchdowns. Green Bay also found success on the ground, rushing for 179 yards on 38 attempts. Arizona’s defense forced just one interception and didn’t come up with any sacks in the game.

Opposing quarterbacks completed 68.8% of their passes against Arizona, and the Cardinals allowed the Packers to convert on 58.3% of their third down attempts. The Cardinals’ inability to generate a pass rush was evident in their performance, as they allowed a high number of passing yards and four touchdowns through the air.

Chargers vs Cardinals Trends

  • Through their last ten road games, Los Angeles has an ATS record of just 5-5. However, their overall record was 5-5 while averaging 18 points per game.
  • Arizona has a 1-2 record in their last three home games. In this stretch, they averaged 21 points per game while allowing 30. The team also performed well vs the spread at 2-1.
  • Going back to their previous three games as the underdog, Arizona has an ATS mark of 1-2 while going 1-2 straight up.
  • As the betting favorite, the Chargers have an ATS record of 3-0 in their last three games. In these matchups, their straight up record was 3-0.

Chargers vs Cardinals Prediction

For this week seven matchup between the Chargers and Cardinals, we have the Chargers coming out on top by a score of 27-22. Even though the Cardinals are the home team, our pick vs. the spread is to take the Chargers to cover, as they are currently sitting at -2.5 point favorites.

As for the over/under, with the line at 43.5 points, we have a projected score of 49 points, making the over our recommended play for this matchup.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.