The San Francisco 49ers will face off against the Buffalo Bills at 8:20 ET on Sunday, December 1st. This matchup is being played at Highmark Stadium in Orchard Park.

The 49ers and Bills are set to kick off at 8:20 ET on Sunday, December 1st, with NBC handling the television coverage. The Bills are the heavy favorite in this one, with their money line sitting at -319. The 49ers’ money line odds are +252, and they are +7 point underdogs on the road. This non-conference matchup is being played at Highmark Stadium in Orchard Park, NY, and the over/under line is at 45.5 points.

• Date: Sunday, December 1st
• Time: 8:20 ET
• Location: Highmark Stadium, Orchard Park
• TV: NBC

49ers vs Bills

Heading into week 13, the 49ers are looking to snap a two-game losing streak, which includes a 38-10 loss to the Packers in week 12. San Francisco was a 6.5-point underdog in that game, but they couldn’t cover the spread. The O/U line was 44.5 points, and the teams combined for 48. In week 11, the 49ers lost 20-17 to the Seahawks, dropping their record to 5-6.

According to our power rankings, the 49ers rank 7th in the NFL, and they have a 16.4% chance of making the playoffs. They are 4-7 against the spread this season, with an average scoring margin of 0 points per game. Their O/U record is 6-5, with their games averaging 47.3 points per game.

With six straight wins, the Bills are now 9-2 and sit atop the AFC East. Our projections give them a 100% chance of winning the division and making the playoffs. Buffalo ranks 3rd in our NFL power rankings heading into week 13.

Buffalo has a +9.6 scoring margin and is 7-4 against the spread. They covered in two straight games, including a 9-point win over the Chiefs in week 11. The over has hit in three straight Bills games, including week 11, when they and the Chiefs combined for 51 points, surpassing the 47-point line.

49ers Injury Report

• Jon Feliciano – Knee (Out)
• Trent Williams – Ankle (Questionable)
• Javon Hargrave – Triceps (Out)
• Kevin Givens – Groin (Questionable)
• Dre Greenlaw – Achilles (Out)
• Nick Bosa – Hip/oblique (Questionable)
• Charvarius Ward – Personal (Questionable)
• Brock Purdy – Right Shoulder (Questionable)
• Drake Jackson – Knee (Out)
• Talanoa Hufanga – Wrist (Out)
• Curtis Robinson – Knee (Out)
• Ambry Thomas – Forearm (Out)
• Elijah Mitchell – Hamstring (Out)
• Aaron Banks – Concussion (Questionable)
• Brandon Aiyuk – Knee (Out)
• Demetrius Flannigan-Fowles – Knee (Questionable)
• Mitch Wishnowsky – Back (Out)
• Jordan Elliott – Concussion (Questionable)
• Tatum Bethune – Knee (Out)
• Darrell Luter Jr. – Pelvis (Out)
• Jacob Cowing – Concussion (Questionable)
• Renardo Green – Neck (Questionable)

Bills Injury Report

• Travis Clayton – Shoulder (Out)
• DeWayne Carter – Wrist (Out)
• Tylan Grable – Groin (Out)
• Keon Coleman – Wrist (Questionable)
• Baylon Spector – Calf (Out)
• Dalton Kincaid – Knee (Questionable)
• Shane Buechele – Neck (Out)
• Tommy Doyle – Undisclosed (Out)
• Spencer Brown – Ankle (Questionable)
• Matt Milano – Bicep (Questionable)
• Dawuane Smoot – Wrist (Out)

49ers Offense Breakdown

Heading into week 13, the 49ers rank 12th in our offensive power rankings, averaging 23.6 points per game, which is 13th in the NFL. They are 4th in passing yards per game (246.2) despite ranking 20th in pass attempts. San Francisco is 7th in rushing, with 138.4 yards per game, and they rank 6th in 3rd-down conversion percentage. However, they are 21st in red zone conversion percentage, despite being 6th in red zone attempts.

In week 12, the 49ers struggled offensively, scoring just 10 points in a loss to the Packers. Brandon Allen threw for 197 yards, going 17/29 with 1 touchdown and 1 interception. Christian McCaffrey had 31 rushing yards on 11 carries, and George Kittle led the team with 82 receiving yards on 6 catches.

Bills Offense Breakdown

Josh Allen has been busy in the passing game, with 40 attempts in week 11, finishing with 262 yards, one touchdown, and one interception. His passer rating improved from 60 in week 10 to 83 in week 11. Allen also led the team in rushing against the Chiefs, with 55 yards on 12 carries. Khalil Shakir was his top target, catching 8 passes for 70 yards.

Buffalo ranks 3rd in the NFL in points per game, averaging 29.1, and they are 9th in 3rd-down conversion percentage. However, they are struggling in the red zone, ranking 28th in conversion percentage, despite being 2nd in red zone attempts.

49ers Team Defense

In their 38-10 loss to the Packers, the 49ers’ defense gave up 169 rushing yards on 42 attempts, which is 4.0 yards per attempt. They allowed two rushing touchdowns and struggled to stop the run throughout the game. Despite this, they did manage to sack the quarterback twice and had two more tackles for loss than the Packers.

Against the pass, the 49ers gave up just 156 yards on 13 completions. However, two of those completions went for touchdowns. The 49ers also allowed the Packers to convert on 46.2% of their third down attempts.

Bills Team Defense

In their 30-21 win over the Chiefs, Buffalo’s defense gave up 181 passing yards, with Kansas City completing 23 passes. The Bills’ run defense allowed 78 yards on just 17 attempts. Despite their good play overall, they did give up three passing touchdowns. Buffalo’s defense also came away with two interceptions.

Opposing offenses are completing 69.7% of their passes against Buffalo. On 3rd down, the Bills are allowing a 50% conversion rate. They also had two sacks in the game.

49ers vs Bills Trends

• When looking at their past three road matchups, San Francisco has an ATS record of 1-2 while averaging 23 per game. The team went 2-1 overall in these games.
• Across the Bills last ten home games, the team averaged 24 points per game while allowing 20. Their record vs the spread in these contests was 6-4, while going 7-3 straight-up.
• Looking back on the team’s last five games as the underdog, the 49ers have a straight up record of 1-4. Their record vs the spread in these games was 2-3.
• In their last five games as the betting favorite, the Bills have a strong straight up record of 5-0. In addition, their ATS record was 4-1 in these scenarios.

49ers vs Bills Prediction

Our pick vs. the spread is to take the 49ers to cover as road underdogs in this week 13 matchup between the 49ers and Bills. The point spread line has the 49ers at +7, and we have them winning 20-18 over the Bills.

For the over/under line, we have a pick to take the under, with a projected combined score of 38 points, well below the O/U line of 45.5.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.