The Detroit Lions will face off against the Indianapolis Colts at 1:00 ET on Sunday, November 24th. This matchup is being played at Lucas Oil Stadium in Indianapolis.

The Lions are favored on the road with a money line of -365 as they take on the Colts at 1:00 ET on Sunday, November 24th. The Colts, the underdog at +290 on the money line, are +7.5 point underdogs at Lucas Oil Stadium in Indianapolis. This non-conference matchup is being televised on FOX, and the over/under line is set at 51 points.

• Date: Sunday, November 24th
• Time: 1:00 ET
• Location: Lucas Oil Stadium, Indianapolis
• TV: FOX

Lions vs Colts

With eight straight wins, the Lions sit atop our NFL power rankings and have a 99.9% chance of making the playoffs. They are 9-1, including a 5-0 record on the road. In week 11, Detroit easily handled the Jaguars, winning 52-6. They were favored by 14 points and covered the spread, bringing their ATS record to 8-2 this season.

On average, the Lions are outscoring their opponents by 15.9 points per game. Their O/U record is 5-4-1, with their games averaging 51.3 points. The O/U line for their week 11 matchup with Jacksonville was 47.5, and the teams combined for 58 points.

After three straight losses, the Colts got back in the win column in week 11, narrowly defeating the Jets 28-27. This improved their record to 5-6, putting them 8th in the AFC and 2nd in the AFC South. Our projections give them a 32.6% chance of making the playoffs and a 5% chance of winning the division. Heading into week 12, they rank 25th in our power rankings.

Despite their negative scoring margin (-1.3), the Colts are 8-3 against the spread, including a 6-2 record as underdogs. Their O/U record is 5-6, with the over hitting in their last two games.

Lions Injury Report

• Allen Robinson II – Concussion (Questionable)
• Alex Anzalone – Forearm (Out)
• Kyle Peko – Pectoral (Out)
• Jalen Reeves-Maybin – Neck (Out)
• Marcus Davenport – Elbow (Out)
• Michael Badgley – Hamstring (Out)
• Emmanuel Moseley – Pectoral (Questionable)
• John Cominsky – Knee (Out)
• Netane Muti – Shoulder (Out)
• David Bada – Achilles (Out)
• Aidan Hutchinson – Tibia (Out)
• Sam LaPorta – Shoulder (Questionable)
• Shane Zylstra – Neck (Questionable)
• Derrick Barnes – Knee (Out)
• Connor Galvin – Knee (Out)
• Antoine Green – Concussion (Out)
• Brodric Martin – Knee (Questionable)
• Nate Lynn – Shoulder (Out)

Colts Injury Report

• Ryan Coll – Undisclosed (Out)
• Jaylon Carlies – Ankle (Out)
• Daniel Scott – Achilles (Out)
• JuJu Brents – Knee (Out)
• Trevor Denbow – Knee (Out)
• Wesley French – Ankle (Out)
• Jelani Woods – Toe (Out)
• Bernhard Raimann – Knee (Questionable)
• Will Fries – Tibia (Out)
• Juwann Winfree – Undisclosed (Out)
• Ryan Kelly – Calf (Out)
• Tyquan Lewis – Elbow (Out)
• Samson Ebukam – Achilles (Out)

Lions Offense Breakdown

Our offensive power rankings have the Lions sitting 2nd in the NFL, and they lead the league in scoring with 33.6 points per game. They are 3rd in total yards, averaging 394.7 per game, and rank 6th in passing yards with 242.5 per game, despite being 26th in pass attempts. On the ground, they are 3rd in both rushing yards (152.2) and attempts per game. Detroit is 6th in the NFL in 3rd-down conversion percentage but ranks 27th in red zone conversion percentage.

Jared Goff is coming off a huge game in week 11, throwing for 412 yards and 4 touchdowns without an interception, posting a perfect passer rating of 158.3. Amon-Ra St. Brown had 11 catches for 161 yards and 2 touchdowns, while David Montgomery rushed for 75 yards and 2 scores. The Lions scored in every quarter, putting up 52 points in their win over the Jaguars.

Colts Offense Breakdown

Heading into week 12, the Colts sit 24th in our offensive power rankings. They are 18th in the NFL in points per game (21.5) and 21st in yards per game, averaging 320.7. In the passing game, they rank 20th in both attempts (30.4) and yards (202.2) per game. On the ground, they are 20th in rushing attempts and 16th in rushing yards per game, with 118.5.

Anthony Richardson threw for 272 yards and a touchdown in week 11, completing 20 of 30 passes without an interception. Jonathan Taylor had 24 carries for 57 yards, while Josh Downs led the team with 5 catches for 84 yards. The Colts converted 6 of 15 third downs and scored on 3 of 4 red zone trips in their win over the Jets.

Lions Team Defense

The Lions’ defense was dominant in their 52-6 win over the Jaguars, allowing just 170 total yards and forcing the Jaguars to a 20% third-down conversion rate. Detroit gave up only 41 rushing yards on 17 attempts and 129 passing yards. They didn’t allow a passing touchdown and came up with one interception.

On top of that, the Lions’ defense managed to get one sack and won the quarterback hit battle. The Jaguars completed just 58.6% of their passes against Detroit.

Colts Team Defense

In their 28-27 win over the Jets, the Colts’ defense gave up 162 passing yards on 22 completions. The Colts allowed two passing touchdowns and the Jets had a 75.9% completion percentage. Indianapolis defended the run well, allowing just 91 yards on 20 attempts (4.6 yards per attempt).

Despite their good run defense, the Colts struggled to get off the field, allowing the Jets to convert on 46.7% of their third downs. Indianapolis did manage three sacks in the game.

Lions vs Colts Trends

• Detroit has played well in their previous 5 road games, going 5-0 straight up. In this stretch, they averaged 29 points per game while allowing 17. The team also performed well vs the spread at 4-1.
• Indianapolis has a 2-3 record in their last five home games. In this stretch, they averaged 23 points per game while allowing 25. The team also performed well vs the spread at 4-1.
• The last ten games that Indianapolis was the underdog, they have an ATS mark of 6-4 while going 3-7 straight up.
• Through their last three games as the favorite, the Lions have an ATS record of 2-1 and a straight up mark of 3-0.

Lions vs Colts Prediction

Our pick vs. the spread is to take the Lions to cover as road favorites in this week 12 matchup between the Colts and Lions. The point spread is currently at 7.5 in favor of the Colts, and we have the Lions pulling off the upset by a score of 31-22.

For this game, we have a lot of confidence in taking the over, as the point spread is currently at 51 points, and our projections have these teams finishing with 53 combined points.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.