The NFL is back! The first games of the season kicks off on Thursday night, and the rest of the weekend’s matchups are sure to be exciting. There are a lot of questions heading into this season: Can Tom Brady or Aaron Rodgers lead their teams to the playoffs? Will the Dallas Cowboys finally live up to their potential? What will Jimmy Garoppolo do in San Francisco? We’ll find out the answers to these questions and more over the next few months. In the meantime, let’s take a look at some of the matchups for week 1.

NFL Regular Season Week 1 Betting Outlook

It’s the first week of regular season action in the NFL, and we anticipate some incredible games.

Today we’re going to take a look at each of these games and make our picks.

New York Giants vs. Tennessee Titans – September 11, 2022 3:25pm CST

Kicking off the afternoon games is an interesting matchup. Daniel Jones struggled last year as the Giants quarterback but still kept his starting spot. Unfortunately, he’s facing one of the best teams in the AFC this week, the Tennessee Titans. 

The tale of the tape for the Titans begins and ends with Derrick Henry. Henry was the leagues leading rusher until an injury forced him to the sidelines. We expect a dominant performance from Henry to start the season and a win for the Titans at home.

Indianapolis Colts vs. Houston Texans – September 11, 2022 12:00pm CST

The Indianapolis Colts come into this game as heavy favorites, and for good reason. Matt Ryan, who was formerly with the Atlanta Falcons, is the Colts’ new quarterback. The good news for Ryan is he now has a solid offensive line in front of him. 

Jonathan Taylor will likely do the heavy lifting for the Colts, beating down the Texan’s defense. This game is pretty clear-cut for us; take the Colts -7.5 to win this game on the road.

* All odds provided by Action247 Sportsbook and all odds subject to change.
**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.