The NBA Regular Season kicks off with the Philadelphia 76ers taking on the Boston Celtics at TD Garden. Both teams start with a clean slate as they meet on Wednesday, October 22, 2025, at 7:30 PM. Fans can catch the game on NBCS.

76ers vs. Celtics Betting Prediction

• Spread Prediction: 76ers -2.5 (-111). The 76ers are the underdog, but they have a chance to cover the spread with a strong performance in the season opener.
• Over/Under Prediction: Under 228 (-112). Both teams might take some time to find their rhythm at the start of the season, which could lead to a lower-scoring game.

Team Trends

• The Philadelphia 76ers and Boston Celtics both start the NBA season with a 0-0 record.
• This game takes place at the TD Garden, home of the Boston Celtics.
• Tip-off is scheduled for 7:30 PM on Wednesday, October 22, 2025.
• Fans can watch the game on the NBCS channel.
• This game marks the beginning of the NBA Regular Season for both teams.

76ers vs Celtics Preview

The Philadelphia 76ers and Boston Celtics are ready to start the NBA season at TD Garden. The 76ers will rely on Joel Embiid in the center position. Tyrese Maxey is expected to lead the backcourt alongside VJ Edgecombe. Kelly Oubre Jr. and Eric Gordon will add depth on the wings.

The Celtics’ lineup features Anfernee Simons and Payton Pritchard in the backcourt. Derrick White and Jaylen Brown will provide scoring from the wings. Neemias Queta will anchor the center position. Both teams aim to start the season with a victory in front of a lively crowd. Fans can watch the action unfold on NBCS.

Boston Celtics Ready for Season Opener

The Boston Celtics are set to begin their NBA season at TD Garden. This game marks the start of a new journey for the Celtics. Fans are eager to see how the team will perform this season. The Celtics have a history of strong performances at home. Playing at TD Garden often gives them an edge. The energy from the home crowd can be a big boost for the team. As the season starts, the Celtics aim to set a positive tone. They will look to their key players to lead the way. The first game against the Philadelphia 76ers will be an important test.

Philadelphia 76ers Set for Season Start

The Philadelphia 76ers are gearing up for the new season under Head Coach Nick Nurse. They play in the Eastern Conference and are part of the Atlantic Division. Their preseason record was 1-3, ending with a win. The 76ers face some challenges with key players out due to injuries. Paul George, Trendon Watford, and Jared McCain will miss the start of the season. Despite these setbacks, the team looks to Tyrese Maxey and Joel Embiid for leadership. During the preseason, Tyrese Maxey showed strong performance, averaging 18.5 points per game. Joel Embiid also contributed, with 14 points and 7 rebounds in his game. The team will rely on these players to set the pace against the Celtics.

Final Betting Pick

The 76ers are set to cover the spread at -2.5. Despite being the underdog, their recent preseason win shows they can perform well. With Nick Nurse as the head coach, the team might have a strong strategy to start the season.

The prediction for the game to go under 228 points seems likely. Both teams are just beginning their regular season, so they might not score as much. This can lead to a lower-scoring game, making the under a good choice.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.