Iowa State Cyclones vs Mississippi State Bulldogs NCAAB Betting Prediction
PublishedNovember 10, 2025,            Posted By: Maria Uebelhor
Last updated:November 10, 2025 ,

NCAAB Iowa State Cyclones vs Mississippi Prediction 11/10

The #16 Iowa State Cyclones will take on the Mississippi State Bulldogs on Monday, November 10, 2025, at 8:00 PM ET. This non-conference game will be held at the Sanford Pentagon in Sioux Falls, SD, a neutral site. Fans can catch the action on ESPNU, with the Cyclones entering as the favorites with a spread of -4.5.

Iowa State vs. Mississippi State Betting Prediction

  • Spread Prediction: Iowa State -4.5. Iowa State has a strong start with a 2-0 record and is ranked #16. They have covered the spread in both games this season.
  • Over/Under Prediction: Over 150.5. Iowa State scores 95 points per game, and Mississippi State scores 86 points per game. Both teams have high scoring potential, making the over a good choice.

Team Trends

  • The game between Iowa State Cyclones and Mississippi State Bulldogs will be held at a neutral site, Sanford Pentagon in Sioux Falls, SD.
  • Iowa State Cyclones are favored with a spread of -4.5, while Mississippi State Bulldogs have a spread of +4.5.
  • The over/under for the game is set at 150.5.
  • Iowa State Cyclones have a perfect record of 2-0 both straight up and against the spread this season.
  • Mississippi State Bulldogs have a straight-up record of 1-0, but are 0-1 against the spread.

Iowa State vs Mississippi State Preview

The Iowa State Cyclones, ranked #16, are set to play against the Mississippi State Bulldogs at the Sanford Pentagon. This non-conference game will be on Monday, November 10, 2025, at 8:00 PM ET. With a spread of -4.5, Iowa State is the favorite, and fans can watch the game on ESPNU.

Iowa State comes into this game with a 2-0 record, having played both games at home. Mississippi State holds a 1-0 record, also from a home game. Both teams are starting their season with this neutral site matchup, aiming to add another win to their records.

Mississippi State Bulldogs: Season Opener Insights

The Mississippi State Bulldogs are ready to start their season. They play in the Southeastern Conference. This game against Iowa State will be their first away from home this season. The Bulldogs scored an average of 86 points in their first game. Their field goal attempts per game rank 36th with 71 shots. However, their field goal percentage is 43.7, which ranks 237th. Josh Hubbard leads the team with 27 points in their first game. Quincy Ballard also made an impact with 8 points and 7 rebounds. Sergej Macura grabbed 12 rebounds, helping the team with strong defense.

Iowa State Cyclones: Ready for Action

The Iowa State Cyclones enter the game with a 2-0 record. They are ranked 16th in the AP poll. This will be their first game away from home this season. Offensively, the Cyclones have been strong. They score 95 points per game, ranking 56th. Their effective field goal percentage is 62.4, which is 28th in the nation. Key players for Iowa State include Tamin Lipsey and Joshua Jefferson. Lipsey averages 14 points and 5 rebounds per game. Jefferson contributes with 17 points and 9 rebounds per game.

Final Betting Pick

Iowa State is favored by 4.5 points, and this looks like a solid pick. They have a strong start with a 2-0 record and are ranked #16. Their ability to cover the spread in both games this season shows they can meet expectations. Their scoring average of 95 points per game is impressive, and they have a high field goal percentage.

The over of 150.5 points is also a good choice. Iowa State scores 95 points per game, and Mississippi State scores 86 points per game. Both teams have high-scoring offenses, which makes hitting the over likely. The neutral site at Sanford Pentagon should not affect the scoring potential of these teams.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.